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논문 기본 정보

자료유형
학술저널
저자정보
Khishigjargal Batsukh (First Central Hospital of Mongolia) Sung-Eun Lee (The Catholic University of Korea College of Medicine) Gi June Min (The Catholic University of Korea College of Medicine) Sung Soo Park (The Catholic University of Korea College of Medicine) Young-Woo Jeon (The Catholic University of Korea College of Medicine) Jae-Ho Yoon (The Catholic University of Korea College of Medicine) Byung-Sik Cho (The Catholic University of Korea College of Medicine) Ki-Seong Eom (The Catholic University of Korea College of Medicine) Yoo-Jin Kim (The Catholic University of Korea College of Medicine) Hee-Je Kim (The Catholic University of Korea College of Medicine) Seok Lee (The Catholic University of Korea College of Medicine) Seok-Goo Cho (The Catholic University of Korea College of Medicine) Dong-Wook Kim (The Catholic University of Korea College of Medicine) Jong Wook Lee (The Catholic University of Korea College of Medicine) Woo-Sung Min (The Catholic University of Korea College of Medicine) Chang-Ki Min (The Catholic University of Korea College of Medicine)
저널정보
대한면역학회 Immune Network Immune Network Vol.17 No.4
발행연도
2017.8
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250 - 260 (11page)

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This retrospective study aimed to compare the clinical features of paramedullary lesions (PLs) and extramedullary lesions (ELs) of plasmacytomas at diagnosis, using positron emission tomography integrated with computed tomography, using glucose labeled with the positron-emitting radionuclide 18F (18F-FDG-PET/CT) in newly diagnosed multiple myeloma (NDMM), and to address their prognostic impact. Sixty-four patients with NDMM presenting ELs (n=22) and/or PLs (n=42) were included. Patients with ELs at initial presentation had unfavorable laboratory parameters of calcium and lactate dehydrogenase, a higher percentage of bone marrow plasma cells, and showed a trend toward advanced international staging system (ISS), compared to patients with PLs. Using X-ray imaging, high bone disease (HBD) was observed in 50% and 71% of patients with ELs and PLs, respectively. After a median follow-up of 29.2 months (range, 3.4–76.5 months) in survivors, patients with ELs had a significantly lower overall survival (OS) (p=0.033) than patients with PLs did, whereas the progression-free survival (PFS) did not differ significantly (p=0.818). However, the PFS after 1st progression was significantly worse in patients with ELs than in those with PLs (p=0.017). In the multivariate analyses, the negative impact of initial ELs on OS (p=0.033) was sustained. Our results demonstrated the different clinical features and outcomes of ELs and PLs in NDMM. Patients with initial ELs showed a shorter PFS after 1<SUB>st</SUB> progression, which translated into poor OS, providing insight into the different biological effect of ELs.
#Multiple myeloma #Plasmacytomas #< #SUP> #18< #/SUP> #F-FDG-PET/CT

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ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES

참고문헌 (21)

참고문헌 신청
Palumbo A, Anderson K. Multiple myeloma. N Engl J Med 2011;364:1046-1060. Blade J, Fernandez de Larrea C, Rosinol L, Cibeira MT, Jimenez R, Powles R. Soft-tissue plasmacytomas in multiple myeloma: incidence, mechanisms of extramedullary spread, and treatment approach. J Clin Oncol 2011;29:3805-3812. Wu P, Davies FE, Boyd K, Thomas K, Dines S, Saso RM, Potter MN, Ethell ME, Shaw BE, Morgan GJ. The impact of extramedullary disease at presentation on the outcome of myeloma. Leuk Lymphoma 2009;50:230-235. Varettoni M, Corso A, Pica G, Mangiacavalli S, Pascutto C, Lazzarino M. Incidence, presenting features and outcome of extramedullary disease in multiple myeloma: a longitudinal study on 1003 consecutive patients. Ann Oncol 2010;21:325-330. Dimopoulos M, Terpos E, Comenzo RL, Tosi P, Beksac M, Sezer O, Siegel D, Lokhorst H, Kumar S, Rajkumar SV, et al. International myeloma working group consensus statement and guidelines regarding the current role of imaging techniques in the diagnosis and monitoring of multiple Myeloma. Leukemia 2009;23:1545-1556.

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