지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.8
- 수록면
- 290 - 299 (10page)
이용수
초록· 키워드
오류제보하기
BACKGROUND/OBJECTIVES: Spirulina is a known a functional food related to lipid profiles, immune functions, and antioxidant capacity. Circulating monocyte chemoattractant protein-1 (MCP-1) level is associated with inflammation markers. Single nucleotide polymorphism in the MCP-1 promoter region -2518 have been identified and shown to affect gene transcription. Gene variation may also impact functional food supplementary effects. The current study investigated the interaction of MCP-1 -2518 polymorphism with spirulina supplements on anti-inflammatory capacity in Korean elderly.
SUBJECTS/METHODS: After genotyping, healthy elderly subjects (n = 78) were included in a randomized, double blind, and placebo controlled study. Baseline characteristic, body composition, and dietary intake were measured twice (baseline vs. week 16). For 16 weeks, subjects consumed 8 g either spirulina or placebo daily. Plasma MCP-1, interleukin (IL) -2, IL-6, tumor necrosis factor (TNF)-α, complement (C) 3, immunoglobulin (Ig) G, and Ig A concentrations and lymphocyte proliferation rate (LPR) were analyzed as inflammatory markers.
RESULTS: In the placebo group with A/A genotype, MCP-1 level was significantly increased, but the spirulina group with A/A genotype was unchanged. IL-2 was significantly increased only in subjects with spirulina supplementation. TNF-α was significantly reduced in subjects with the G carrier. C3 was significantly increased in the placebo group, particularly when A/A increased more than G, but not when spirulina was ingested. LPR was significantly different only in subjects with A/A genotype; there was a significant increase in phytohemagglutinin and lipopolysaccharide induced LPR in the spirulina group.
CONCLUSION: In healthy Korean elderly, spirulina supplementation may influence different inflammatory markers by the MCP-1 genotype. These results may be useful for customized dietary guidelines to improve immune function in Koreans.
SUBJECTS/METHODS: After genotyping, healthy elderly subjects (n = 78) were included in a randomized, double blind, and placebo controlled study. Baseline characteristic, body composition, and dietary intake were measured twice (baseline vs. week 16). For 16 weeks, subjects consumed 8 g either spirulina or placebo daily. Plasma MCP-1, interleukin (IL) -2, IL-6, tumor necrosis factor (TNF)-α, complement (C) 3, immunoglobulin (Ig) G, and Ig A concentrations and lymphocyte proliferation rate (LPR) were analyzed as inflammatory markers.
RESULTS: In the placebo group with A/A genotype, MCP-1 level was significantly increased, but the spirulina group with A/A genotype was unchanged. IL-2 was significantly increased only in subjects with spirulina supplementation. TNF-α was significantly reduced in subjects with the G carrier. C3 was significantly increased in the placebo group, particularly when A/A increased more than G, but not when spirulina was ingested. LPR was significantly different only in subjects with A/A genotype; there was a significant increase in phytohemagglutinin and lipopolysaccharide induced LPR in the spirulina group.
CONCLUSION: In healthy Korean elderly, spirulina supplementation may influence different inflammatory markers by the MCP-1 genotype. These results may be useful for customized dietary guidelines to improve immune function in Koreans.
목차
NTRODUCTION
SUBJECTS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (61)
참고문헌 신청
Muller WA. Getting leukocytes to the site of inflammation. Vet Pathol 2013;50:7-22.
Xu L, Rocnik E, Rahlpour R, Hunter N, Pickering G, Kelvin DJ. MCP-1 induces proliferation and migration of vascular smooth muscle cells. FASEB J 1996;10:A1932.
Luster AD. Chemokines--chemotactic cytokines that mediate inflammation. N Engl J Med 1998;338:436-45.
Rossi D, Zlotnik A. The biology of chemokines and their receptors. Annu Rev Immunol 2000;18:217-42.
Salcedo R, Ponce ML, Young HA, Wasserman K, Ward JM, Kleinman HK, Oppenheim JJ, Murphy WJ. Human endothelial cells express CCR2 and respond to MCP-1: direct role of MCP-1 in angiogenesis and tumor progression. Blood 2000;96:34-40.
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Monocyte chemoattractant protein-1 polymorphism interaction with spirulina immunomodulatory effects in healthy Korean elderly : A 16-week, double-blind randomized clinical trial
Nutrition Research and Practice
2017 .08
-
The influence of obesity on the effects of spirulina supplementation in the human metabolic response of Korean elderly
Nutrition Research and Practice
2016 .08
-
The influence of obesity on the effects of spirulina supplementation in the human metabolic response of Korean elderly
Nutrition Research and Practice
2016 .08
-
Development of a Spirulina Extract/Alginate-Imbedded PCL Nanofibrous Cosmetic Patch
Journal of Microbiology and Biotechnology
2017 .01
-
MCP-1에 의해 유도된 THP-1 유주에 미치는 Zerumbone의 영향
대한임상검사과학회지
2018 .01
-
Whole genome detection of recent selection signatures in Sarabi cattle: a unique Iranian taurine breed
Genes & Genomics
2020 .01
-
Effect of saccharin on inflammation in 3T3-L1 adipocytes and the related mechanism
Nutrition Research and Practice
2020 .04
-
Effect of saccharin on inflammation in 3T3-L1 adipocytes and the related mechanism
Nutrition Research and Practice
2020 .04
-
Effects of methionine synthase and methionine synthase reductase polymorphisms on hypertension susceptibility
Genes & Genomics
2020 .01
-
Tuberculosis risk is associated with genetic polymorphisms in the LRP2, CUBN, and VDR genes
Genes & Genomics
2020 .01
-
The Effect of Onion Peel Extract on Inflammatory Mediators in Korean Overweight and Obese Women
Clinical Nutrition Research
2016 .01
-
Agrobacterium sp.-derived β-1,3-glucan enhances natural killer cell activity in healthy adults : a randomized, double-blind, placebo-controlled, parallel-group study
Nutrition Research and Practice
2017 .02
-
Agrobacterium sp.-derived β-1,3-glucan enhances natural killer cell activity in healthy adults : a randomized, double-blind, placebo-controlled, parallel-group study
Nutrition Research and Practice
2017 .02
-
Purification and Identification of Antioxidant Peptides from Enzymatic Hydrolysate of Spirulina platensis
Journal of Microbiology and Biotechnology
2016 .01
-
Lifestyle intervention might easily improve blood pressure in hypertensive men with the C genotype of angiotensin II type 2 receptor gene
Nutrition Research and Practice
2015 .08
-
Lifestyle intervention might easily improve blood pressure in hypertensive men with the C genotype of angiotensin II type 2 receptor gene
Nutrition Research and Practice
2015 .08
-
MCP-1에 의해 유도된 THP-1 유주에 미치는2-methoxy-1,4-naphthoquinone (MQ)의 영향
대한임상검사과학회지
2019 .01
-
[Erratum] Onion peel extract reduces the percentage of body fat in overweight and obese subjects: a 12-week, randomized, double-blind, placebo-controlled study
Nutrition Research and Practice
2016 .06
-
[Erratum] Onion peel extract reduces the percentage of body fat in overweight and obese subjects: a 12-week, randomized, double-blind, placebo-controlled study
Nutrition Research and Practice
2016 .06
-
Effects of glutathione s-transferase (GST) M1 and T1 polymorphisms on antioxidant vitamins and oxidative stress-related parameters in Korean subclinical hypertensive subjects after kale juice (Brassica oleracea acephala) supplementation
Nutrition Research and Practice
2018 .04
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2018-594-001213776