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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.4
- 수록면
- 89 - 102 (14page)
이용수
초록· 키워드
오류제보하기
Mesenchymal Stromal Cells (MSCs) are potential cellular candidates for several immunotherapy purposes. Their multilineage potential and immunomodulatory properties make them interesting tools for the treatment of various immunological diseases. However, depending on the local microenvironment, diverse biological functions of MSCs can be modulated. Indeed, during infections such as obtained following TLR-agonist engagement (called as TLR priming), the phenotype, multilineage potential, hematopoietic support and immunomodulatory capacity of MSCs can present critical changes, which could further affect their therapeutic potential. Thus, for appropriate clinical application of MSCs, it is important to well know and understand these effects in particular during infectious episodes and to find the suitable experimental settings to study that. Pre-stimulation of MSCs with a specific TLR ligand may serve as an effective priming step to modulate one of its function to achieve a desired therapeutic issue.
목차
Mesenchymal stromal cells
Sensitivity to infection
Toll-Like Receptors
TLR signaling
MSC and TLR expression
MSC phenotype and TLR-priming
MSC multilineage potential and TLR-priming
MSC hematopoietic support and TLR-priming
MSC immunomodulation and TLR-priming
Conclusions & perspectives
REFERENCES
참고문헌 (100)
참고문헌 신청
Fayyad-Kazan, M., H. Fayyad-Kazan, L. Lagneaux, and M. Najar. 2016. The potential of mesenchymal stromal cells in immunotherapy. Immunotherapy 8: 839-842.
Hass, R., C. Kasper, S. Bohm, and R. Jacobs. 2011. Different populations and sources of human mesenchymal stem cells (MSC): A comparison of adult and neonatal tissue-derived MSC. Cell Commun. Signal 9: 12.
El, O. R., J. Beroud, J. F. Stoltz, P. Menu, E. Velot, and V. Decot. 2014. Umbilical cord mesenchymal stem cells: the new gold standard for mesenchymal stem cell-based therapies? Tissue Eng. Part B Rev. 20: 523-544.
Owen, M., and A. J. Friedenstein. 1988. Stromal stem cells: marrow-derived osteogenic precursors. Ciba Found. Symp. 136: 42-60.
Caplan, A. I., and D. Correa. 2011. The MSC: an injury drugstore. Cell Stem Cell 9: 11-15.
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