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초록· 키워드
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Bromelain is a protein-digesting (proteolytic) enzyme complex found in the fruit and, in higher concentrations, in the stem of the pineapple (Ananas comosus). It is able to hydrolyze or break down a wide variety of protein types in a range of acid and alkaline environments. Using micro capsule technology, we were able to stabilize bromelain. It features high stabilization for skin care and personal care products.
When we stabilized bromelain using the microencapsulation method, it maintained its enzyme activity at about 68% after 6 months, in 45℃ conditions. We measured spherical stabilized bromelain from 300 to 1,000㎛, utilizing SEM (scanning electron microscopy). Papain, a protein-digesting enzyme which is derived from the papaya is usually utilized in many cosmetic products, however, when compared to stabilized bromelain, with regards to the activity of GDU(Gelatin Digestion Unit), stabilized bromelain showed superior protein digestive activity. After applying the skin care product containing stabilized bromelain for 7 days, we found in our results that it removes dead skin cells and cleans the skin surface. Therefore, this stabilization technology might lead to stabilized bromelain being widely used in various cosmetic products. Bromelain was previously proved by many scientists to proteolytically remove certain cell surface molecules that affects lymphocyte migration and activation 3-9). In addition, bromelain markedly affects the creation of various cytokines and inflammatory effects.
When we stabilized bromelain using the microencapsulation method, it maintained its enzyme activity at about 68% after 6 months, in 45℃ conditions. We measured spherical stabilized bromelain from 300 to 1,000㎛, utilizing SEM (scanning electron microscopy). Papain, a protein-digesting enzyme which is derived from the papaya is usually utilized in many cosmetic products, however, when compared to stabilized bromelain, with regards to the activity of GDU(Gelatin Digestion Unit), stabilized bromelain showed superior protein digestive activity. After applying the skin care product containing stabilized bromelain for 7 days, we found in our results that it removes dead skin cells and cleans the skin surface. Therefore, this stabilization technology might lead to stabilized bromelain being widely used in various cosmetic products. Bromelain was previously proved by many scientists to proteolytically remove certain cell surface molecules that affects lymphocyte migration and activation 3-9). In addition, bromelain markedly affects the creation of various cytokines and inflammatory effects.
목차
ABSTRACT
Ⅰ. 서론
Ⅱ. 재료 및 방법
3. 결과 및 고찰
Ⅳ. 결론
REFERENCES
참고문헌 (10)
참고문헌 신청
Bromelain / WebMD
Laura P. Hale / 2005 / Proteinase activity and stability of natural bromelain preparations / International Immunopharmacology 5:783
Hale LP / 1992 / Bromelain treatment of human T cells removes CD44, CD45RA, E2/MIC2, CD6, CD7, CD8, and Leu 8/LAM1 surface molecules and markedly enhances CD2-mediated T cell activation / J Immunol 149:3809
1996 / Simon Benita Microencapsulation Methods and industrial applications. : A Survey of Microencapsulation Processes
Hale LP / 2002 / Bromelain treatment alters leukocyte expression of cell surface molecules involved in cellular adhesion and activation / Clin Immunol 104:183
Laura P. Hale / 2005 / Proteinase activity and stability of natural bromelain preparations / International Immunopharmacology 5:783
Hale LP / 1992 / Bromelain treatment of human T cells removes CD44, CD45RA, E2/MIC2, CD6, CD7, CD8, and Leu 8/LAM1 surface molecules and markedly enhances CD2-mediated T cell activation / J Immunol 149:3809
1996 / Simon Benita Microencapsulation Methods and industrial applications. : A Survey of Microencapsulation Processes
Hale LP / 2002 / Bromelain treatment alters leukocyte expression of cell surface molecules involved in cellular adhesion and activation / Clin Immunol 104:183
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UCI(KEPA) : I410-ECN-0101-2017-593-002215408