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논문 기본 정보

자료유형
학술저널
저자정보
Jong Won Kim (Chonbuk National University) Hyejin Yun (Chonbuk National University) Seong-Jin Choi (Korea Institute of Toxicology) Sang-Hyub Lee (Korea Institute of Toxicology) Surim Park (Chonbuk National University) Chae Woong Lim (Chonbuk National University) Kyuhong Lee (Jeonbuk Department of Inhalation Research) Bumseok Kim (Chonbuk National University)
저널정보
한국독성학회 Toxicological Research Toxicological Research Vol.33 No.1
발행연도
2017.1
수록면
31 - 41 (11page)

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초록· 키워드

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Side stream cigarette smoke (SSCS) is known to be as harmful and hazardous to human health as is active smoking. In this study, we investigated the relationship between the exposure to SSCS and its stimulatory and subacute effects on the progression of non-alcoholic steatohepatitis (NASH). A methionine and choline-deficient plus high fat (MCDHF) diet was administered to C57BL/6 mice for 6 weeks. During the first three weeks of MCDHF diet feeding, each diet group was exposed to SSCS (0, 20, 40 μg/L) or fresh air for 2 hrs per day and 5 days per week. Additional experiments were performed by increasing the concentration (0, 30, 60 μg/L) and exposure time (6 hours per day) of SSCS. According to histopathologic analysis and serum levels of Alanine Aminotransferase (ALT) and Aspartate Aminotransferase (AST), there were no differences in hepatic fat deposition, fibrosis, apoptosis or liver damage in MCDHF-fed mice based on SSCS exposure. There were also no differences in the expression of inflammation-, oxidative stress- or fibrosis-related genes between MCDHF-fed mice with or without SSCS exposure. Therefore, it is concluded that SSCS with current exposure amounts does not have additive detrimental effects on the early stage of NASH.

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INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES

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UCI(KEPA) : I410-ECN-0101-2017-513-002054367