지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.12
- 수록면
- 351 - 359 (9page)
- DOI
- 10.14815/kjdm.2016.43.4.351
이용수
초록· 키워드
오류제보하기
Previously, many studies investigating differentiation of osteoclasts, osteoblasts or mesenchymal stem cells alone on titanium with nanotubular structure were reported. However, there is barely information about the effects of oxidized titanium (TiO₂) nanotubular structure on the formation of osteoclast under coculture condition. In this study, we investigated the differentiation and formation of osteoclast cultured on TiO₂ nanotubular structure under coculture condition. Bone marrow cells were cultured with calvarial osteoblast cells on TiO₂ nanotubes with different diameters (30-100 nm). The formation of mature osteoclasts was apparently increased on 30 nm TiO₂ nanotubes compared to that of electropolished titanium surface (Ti), and then dramatically reduced by increasing nanotube diameters up to 100nm. However, the adhesion of osteoclasts or osteoblasts, and the expression of osteoblast differentiation marker genes were not shown any significant difference at all diameters of TiO₂ nanotubular structures. Rather, the expression of osteoclast differentiation factors (macrophage colony-stimulating factor, M-CSF, osteoprotegerin, OPG and receptor activator of nuclear factor kappa-B ligand, RANKL) produced by osteoblasts was dramatically changed by diameters of TiO₂ nanotubular structure. The expression of M-CSF and OPG in osteoblasts was up-regulated, and the expression of RANKL and RANKL/OPG ratio were down-regulated by increasing diameters of TiO₂ nanotubes, in particular, at 70 and 100 nm. These data suggest that the inhibition of osteoclast formation by TiO₂ nanotube having 70-100 nm diameters may due to diminishing function of osteoblast responsible for osteoclast differentiation under coculture condition. It also indicate that the nano-topography on the Ti surface may affect to successful medical application including dental implantation.
목차
〈Abstract〉
Ⅰ. 서론
Ⅱ. 재료 및 방법
Ⅲ. 결과
Ⅳ. 고찰
Ⅴ. 결론
Ⅵ. 참고문헌
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Effects of Advanced Glycation End Products on Differentiation and Function of Osteoblasts and Osteoclasts
Journal of Korean Medical Science
2021 .09
-
Origin of Osteoclasts: Osteoclast Precursor Cells
대한골대사학회지
2023 .05
-
RANK Signaling Pathways and Key Molecules Inducing Osteoclast Differentiation
대한의생명과학회지
2017 .12
-
Effects of Glycine max germinated extract and Angelica gigas extract mixture on osteoblast and osteoclast
한국실험동물학회 학술발표대회 논문집
2022 .07
-
Osteoclasts: Crucial in Rheumatoid Arthritis
대한류마티스학회지
2016 .01
-
극지해면동물 Sphaerotylus antarcticus 추출물의 RANKL 유도 파골세포 분화 및 ROS 생성 억제 효과
생약학회지(Korean Journal of Pharmacognosy)
2022 .03
-
Signaling Pathways in Osteoclast Differentiation
전남의대학술지
2016 .01
-
A2B Adenosine Receptor Stimulation Down-regulates M-CSF-mediated Osteoclast Proliferation
대한의생명과학회지
2017 .09
-
Attenuation of RANKL-induced Osteoclast Formation via p38-mediated NFATc1 Signaling Pathways by Extract of Euphorbia Lathyris L
대한골대사학회지
2016 .01
-
녹제초 추출물이 파골세포 분화 및 골 흡수에 미치는 영향
한방재활의학과학회지
2019 .01
-
백작약 에탄올 추출물의 파골세포 분화 및 생성 억제 작용
동의생리병리학회지
2015 .02
-
백작약 에탄올 추출물의 파골세포 분화 및 생성 억제 작용
동의생리병리학회지
2015 .01
-
The Role of Toll-Like Receptors in Osteoclastogenesis
대한골대사학회지
2020 .01
-
Anti-Mullerian Hormone Negatively Regulates Osteoclast Differentiation by Suppressing the Receptor Activator of Nuclear Factor-κB Ligand Pathway
대한골대사학회지
2021 .08
-
Effects of Sparganii Rhizoma on osteoclast formation and osteoblast differentiation and on an OVX-induced bone loss model
한국실험동물학회 학술발표대회 논문집
2022 .07
-
Biological characteristics of osteoporosis drugs: the effect of osteoblast–osteoclast coupling
International Journal of Oral Biology
2019 .01
-
RANKL에 의한 파골세포의 분화 억제에 대한 isorhamnetin의 효과
생약학회지(Korean Journal of Pharmacognosy)
2023 .12
-
소청룡탕이 파골세포 분화억제와 골흡수에 미치는 영향
대한한의학회지
2017 .09
-
Anti-osteoporotic effects of cornus officinalis in osteoblast and osteoclast cells and ovariectomized mice
한국실험동물학회 학술발표대회 논문집
2020 .02
-
Effects of the Lysine Methyltransferase Inhibitor AZ505 on Bone Metabolism
대한골대사학회지
2021 .11
이 논문의 저자 정보
이 논문과 함께 이용한 논문
한국 성인의 비타민D 섭취량과 혈중 25OHD 농도 및 골밀도와의 관련성 : 2011 국민건강영양조사 결과 재분석
김미연
,
김미자
,
이선영
Journal of Nutrition and Health
2016
.12
Intestinal anti-inflammatory activity of Sasa quelpaertensis leaf extract by suppressing lipopolysaccharide-stimulated inflammatory mediators in intestinal epithelial Caco-2 cells co-cultured with RAW 264.7 macrophage cells
Kyung-Mi Kim
,
Yoo-Sun Kim
,
Ji Ye Lim
외 5명
Nutrition Research and Practice
2015
.02
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2017-515-001974255