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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.10
- 수록면
- 347 - 354 (8page)
- DOI
- 10.15188/kjopp.2016.10.30.5.347
이용수
초록· 키워드
오류제보하기
This study evaluated the effects of Fructus Corni Officinalis water extract (FCE) on congnitive impairment and Aβ clearance induced by beta amyloid Aβ (1-42) injection in the hippocampus of rat. Aβ (1-42) was injected into the hippocampus using a Hamilton syringe and micropump (5 ㎍/5 ㎕, 1 ㎕/min, each hippocampus bilaterally). FCE was administered orally once a day (100, 250, 500 ㎎/㎏) for 4 weeks after the Aβ (1-42) injection. The acquisition of learning and retention of memory were tested using the Morris water maze. Aβ accumulation and Aβ clearance in the hippocampus were observed using immunostaining. Aβ (1-42) level in plasma was confirmed using enzyme-linked immunosorbent assay (ELISA). FCE significantly shortened the escape latencies during acquisition training trials. FCE significantly increased the number of target heading to the platform site and significantly shortened the time for the 1<SUP>st</SUP>targetheadingduringtheretentiontesttrial.FCEsignificantlyattenuatedtheAβ accumulation in the hippocampus produced by Aβ (1-42) injection. FCE significantly increased LRP-1 expression around vessels in the hippocampus and Aβ (1-42) levels in plasma. The results suggest that FCE improved cognitive impairment by ameliorate Aβ clearance and Aβ accumulation in the hippocampus. FCE may be a beneficial herbal formulation in treating cognitive impairment including Alzheimer’s disease.
목차
Introduction
Materials and Methods
Results
Discussion
References
참고문헌 (36)
참고문헌 신청
[학술지(정기간행물)] - Blennow, K. / 2006 / Alzheimer’s disease / Lancet 368 (9533) : 387 ~ 403
[학술지(정기간행물)] - Dickson, D. W. / 1997 / The pathogenesis of senile plaques / J Neuropathol Exp Neurol 56 (4) : 321 ~ 339
[학술지(정기간행물)] - Yates, S. L. / 2000 / Amyloid beta and amylin fibrils induce increases in proinflammatory cytokine and chemokine production by THP-1 cells and murine microglia / J Neurochem 74 (3) : 1017 ~ 1025
[학술지(정기간행물)] - Selkoe, D. J. / 2003 / Alzheimer’s disease: Molecular understanding predicts amyloid-based therapeutics / Annu Rev Pharmacol Toxicol 43 : 545 ~ 584
[학술지(정기간행물)] - Liu, H. / 2012 / Regulation of β-amyloid level in the brain of rats with cerebrovascular hypoperfusion / Neurobiol Aging 33 (826) : 31 ~ 42
[학술지(정기간행물)] - Dickson, D. W. / 1997 / The pathogenesis of senile plaques / J Neuropathol Exp Neurol 56 (4) : 321 ~ 339
[학술지(정기간행물)] - Yates, S. L. / 2000 / Amyloid beta and amylin fibrils induce increases in proinflammatory cytokine and chemokine production by THP-1 cells and murine microglia / J Neurochem 74 (3) : 1017 ~ 1025
[학술지(정기간행물)] - Selkoe, D. J. / 2003 / Alzheimer’s disease: Molecular understanding predicts amyloid-based therapeutics / Annu Rev Pharmacol Toxicol 43 : 545 ~ 584
[학술지(정기간행물)] - Liu, H. / 2012 / Regulation of β-amyloid level in the brain of rats with cerebrovascular hypoperfusion / Neurobiol Aging 33 (826) : 31 ~ 42
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UCI(KEPA) : I410-ECN-0101-2017-519-001647255