지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.91 No.4
- 발행연도
- 2016.10
- 수록면
- 165 - 171 (7page)
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초록· 키워드
오류제보하기
Purpose: The purpose of this study was to evaluate the prognostic significance of serum CEA (s-CEA) changes in colorectal cancer (CRC) patients with sustained elevated postoperative s-CEA levels.
Methods: Between January 1999 and December 2008, 9,380 CRC patients underwent surgery. Curative resection was performed in 1,242 CRC patients with high preoperative s-CEA levels (>6 ng/mL). High s-CEA levels were normalized in 924 patients (74.4%) within 2 weeks from surgery, whereas high s-CEA levels were persistent in 318 patients (25.6%). Patients were divided into 2 groups according to their postoperative s-CEA levels: group 1 (37 patients with a 1-year postoperative s-CEA>6 ng/mL) and group 2 (281 patients with a 1-year postoperative s-CEA≤6 ng/mL).
Results: A postoperative recurrence was identified in 24 patients (64.9%) in group 1 and 65 patients (23.1%) in group 2 (P < 0.001). A curative resection after recurrence was performed in 22 patients (33.8%) from group 2, but no patients from group 1 (P = 0.001). The 5-year overall survival and time to recurrence were significantly lower in patients with recurrent cancer in group 1 (P < 0.001).
Conclusion: Patients with persistent elevated postoperative s-CEA levels are at high risk for recurrence and a low survival rate. More intensive surveillance of patients with high postoperative s-CEA levels should be mandatory.
Methods: Between January 1999 and December 2008, 9,380 CRC patients underwent surgery. Curative resection was performed in 1,242 CRC patients with high preoperative s-CEA levels (>6 ng/mL). High s-CEA levels were normalized in 924 patients (74.4%) within 2 weeks from surgery, whereas high s-CEA levels were persistent in 318 patients (25.6%). Patients were divided into 2 groups according to their postoperative s-CEA levels: group 1 (37 patients with a 1-year postoperative s-CEA>6 ng/mL) and group 2 (281 patients with a 1-year postoperative s-CEA≤6 ng/mL).
Results: A postoperative recurrence was identified in 24 patients (64.9%) in group 1 and 65 patients (23.1%) in group 2 (P < 0.001). A curative resection after recurrence was performed in 22 patients (33.8%) from group 2, but no patients from group 1 (P = 0.001). The 5-year overall survival and time to recurrence were significantly lower in patients with recurrent cancer in group 1 (P < 0.001).
Conclusion: Patients with persistent elevated postoperative s-CEA levels are at high risk for recurrence and a low survival rate. More intensive surveillance of patients with high postoperative s-CEA levels should be mandatory.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (24)
참고문헌 신청
[학술지(정기간행물)] - Chen CH. / 2010 / Lead time of car cinoembryonic antigen elevation in the postoperative follow-up of colorectal cancer did not affect the survival rate after recurrence / Int J Colorectal Dis 25 : 567 ~ 571
[학술지(정기간행물)] - Gold P. / 1965 / Specific carcinoembryonic antigens of the human digestive system / J Exp Med 122 : 467 ~ 481
[학술지(정기간행물)] - Palmqvist R. / 2003 / Pre diagnostic levels of carcinoembryonic anti gen and CA 242 in colorectal cancer : a matched case-control study / Dis Colon Rectum 46 : 1538 ~ 1544
[학술지(정기간행물)] - Wanebo HJ. / 1978 / Preoperative carcinoembryonic antigen level as a prognostic indicator in colorectal cancer / N Engl J Med 299 : 448 ~ 451
[학술지(정기간행물)] - Moertel CG. / 1986 / The preoperative carcinoembryonic antigen test in the diagnosis, staging, and prognosis of colorectal cancer / Cancer 58 : 603 ~ 610
[학술지(정기간행물)] - Gold P. / 1965 / Specific carcinoembryonic antigens of the human digestive system / J Exp Med 122 : 467 ~ 481
[학술지(정기간행물)] - Palmqvist R. / 2003 / Pre diagnostic levels of carcinoembryonic anti gen and CA 242 in colorectal cancer : a matched case-control study / Dis Colon Rectum 46 : 1538 ~ 1544
[학술지(정기간행물)] - Wanebo HJ. / 1978 / Preoperative carcinoembryonic antigen level as a prognostic indicator in colorectal cancer / N Engl J Med 299 : 448 ~ 451
[학술지(정기간행물)] - Moertel CG. / 1986 / The preoperative carcinoembryonic antigen test in the diagnosis, staging, and prognosis of colorectal cancer / Cancer 58 : 603 ~ 610
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UCI(KEPA) : I410-ECN-0101-2017-514-001301380