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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 환경독성보건학회 Environmental Analysis Health and Toxicology Environmental Health and Toxicology Vol.30
- 발행연도
- 2015.12
- 수록면
- 112 - 118 (7page)
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초록· 키워드
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Objectives: Cigarette smoking is associated with carcinogenesis owing to the mutagenic and genotoxic effects of cigarette smoke. The aim of this study was to evaluate the mutagenic and genotoxic effects of Korean cigarettes using in vitro assays.
Methods: We selected 2 types of cigarettes (TL and TW) as benchmark Korean cigarettes for this study, because they represent the greatest level of nicotine and tar contents among Korean cigarettes. Mutagenic potency was expressed as the number of revertants per μg of cigarette smoke condensate (CSC) total particulate matter whereas genotoxic potency was expressed as a concentration-dependent induction factor. The CSC was prepared by the International Organization for Standardization 3308 smoking method. CHO-K1 cells were used in vitro micronucleus (MNvit) and comet assays. Two strains of Salmonella typhimurium (Salmonella enterica subsp. enterica ; TA98 and TA1537) were employed in Ames tests.
Results: All CSCs showed mutagenicity in the TA98 and TA1537 strains. In addition, DNA damage and micronuclei formation were observed in the comet and MNvit assays owing to CSC exposure. The CSC from the 3R4F Kentucky reference (3R4F) cigarette produced the most severe mutagenic and genotoxic potencies, followed by the CSC from the TL cigarette, whereas the CSC from the TW cigarette produced the least severe mutagenic and genotoxic potencies.
Conclusions: The results of this study suggest that the mutagenic and genotoxic potencies of the TL and TW cigarettes were weaker than those of the 3R4F cigarette. Further study on standardized concepts of toxic equivalents for cigarettes needs to be conducted for more extensive use of in vitro tests.
Methods: We selected 2 types of cigarettes (TL and TW) as benchmark Korean cigarettes for this study, because they represent the greatest level of nicotine and tar contents among Korean cigarettes. Mutagenic potency was expressed as the number of revertants per μg of cigarette smoke condensate (CSC) total particulate matter whereas genotoxic potency was expressed as a concentration-dependent induction factor. The CSC was prepared by the International Organization for Standardization 3308 smoking method. CHO-K1 cells were used in vitro micronucleus (MNvit) and comet assays. Two strains of Salmonella typhimurium (Salmonella enterica subsp. enterica ; TA98 and TA1537) were employed in Ames tests.
Results: All CSCs showed mutagenicity in the TA98 and TA1537 strains. In addition, DNA damage and micronuclei formation were observed in the comet and MNvit assays owing to CSC exposure. The CSC from the 3R4F Kentucky reference (3R4F) cigarette produced the most severe mutagenic and genotoxic potencies, followed by the CSC from the TL cigarette, whereas the CSC from the TW cigarette produced the least severe mutagenic and genotoxic potencies.
Conclusions: The results of this study suggest that the mutagenic and genotoxic potencies of the TL and TW cigarettes were weaker than those of the 3R4F cigarette. Further study on standardized concepts of toxic equivalents for cigarettes needs to be conducted for more extensive use of in vitro tests.
목차
Introduction
Materials and Methods
Results
Discussion
REFERENCES
참고문헌 (29)
참고문헌 신청
정규원 / 2015 / Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2012 / Cancer Research and Treatment 47(2):127~141
Ha BM. / 2003 / Measuring the burden of premature death due to smoking in Korea from 1990to 1999 / Public Health 117(5):358~365
Ministry of Health and Welfare / 2012 / Yearbook of health, welfare and family statistics 2009 :39
Choi SH / 2013 / Smoking status of adults and adolescents in Korea / Public Health Wkly Rep KCDC 6(35):702~706
Lu Y. / 2008 / Exposure level to cigarette tar or nicotine is associated with leukocyte DNA damage in male Japanese smokers / Mutagenesis 23(6):451~455
Ha BM. / 2003 / Measuring the burden of premature death due to smoking in Korea from 1990to 1999 / Public Health 117(5):358~365
Ministry of Health and Welfare / 2012 / Yearbook of health, welfare and family statistics 2009 :39
Choi SH / 2013 / Smoking status of adults and adolescents in Korea / Public Health Wkly Rep KCDC 6(35):702~706
Lu Y. / 2008 / Exposure level to cigarette tar or nicotine is associated with leukocyte DNA damage in male Japanese smokers / Mutagenesis 23(6):451~455
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UCI(KEPA) : I410-ECN-0101-2017-539-000798928