지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
이용수
초록· 키워드
오류제보하기
Ultraviolet (UV) irradiation induces cellular damage. A variety of cellular responses for repairing cellular damage including DNA damage occur after UV irradiation. During the repair processes, expression and activation of various molecules are regulated depending on the types of cellular damage. Parkin is an E3 ligase and act as a tumor suppressor. Recently, it has been reported that Parkin is involved in the DNA repair process. In the current study, we investigated whether UVB irradiation influences expression of Parkin. Parkin expression transiently decreased after UVB irradiation both at the mRNA and protein levels, but returned to normal levels thereafter. Taken together with cell viability data, Parkin expression is down-regulated during UVB-induced suppression of cell growth and is increased again in accordance with recovery of UVB-induced cell growth inhibition. However, Parkin overexpression or knockdown did not influence UVB-induced cell growth inhibition and recovery. We propose that Parkin could be a useful molecular marker for evaluating conditions of cells after UVB irradiation.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (21)
참고문헌 신청
Abraham RT. Cell cycle checkpoint signaling through the ATM and ATR kinases. Gene Dev. 2001. 15: 2177-2196.
Asimuddin M, Jamil K. Insight into the DNA repair mechanism operating during cell cycle checkpoints in eukaryotic cells. Biology and Medicine. 2012. 4: 147.
Branzei D, Foiani M. Regulation of DNA repair throughout the cell cycle. Nat Rev Mol Cell Bio. 2008. 9: 297-308.
Carroll RG, Hollville E, Martin SJ. Parkin sensitizes toward apoptosis induced by mitochondrial depolarization through promoting degradation of Mcl-1. Cell Rep. 2014. 9: 1538-1553.
Jackson SP, Bartek J. The DNA-damage response in human biology and disease. Nature. 2009. 461: 1071-1078.
Asimuddin M, Jamil K. Insight into the DNA repair mechanism operating during cell cycle checkpoints in eukaryotic cells. Biology and Medicine. 2012. 4: 147.
Branzei D, Foiani M. Regulation of DNA repair throughout the cell cycle. Nat Rev Mol Cell Bio. 2008. 9: 297-308.
Carroll RG, Hollville E, Martin SJ. Parkin sensitizes toward apoptosis induced by mitochondrial depolarization through promoting degradation of Mcl-1. Cell Rep. 2014. 9: 1538-1553.
Jackson SP, Bartek J. The DNA-damage response in human biology and disease. Nature. 2009. 461: 1071-1078.
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The involvement of Parkin-dependent mitophagy in the anti-cancer activity of Ginsenoside
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The expression of Pink1 and parkin in the mouse uterus during the estrous cycle
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UVB Irradiation Increases the Expression of Pro-inflammatory Cytokine in Jurkat T Cells Exposed to Triglycerides
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Ginsenosides repair UVB-induced skin barrier damage in BALB/c hairless mice and HaCaT keratinocytes
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Ultraviolet B Downregulated Aquaporin 1 Expression via the MEK/ERK pathway in the Dermal Fibroblasts
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자외선B 노출로 인해 손상된 피부세포에 대한 돌배나무잎 추출물의 보호효과
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Identification and Molecular Characterization of Parkin in Clonorchis sinensis
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Hesperidin Attenuates Ultraviolet B-Induced Apoptosis by Mitigating Oxidative Stress in Human Keratinocytes
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Clinical Significance of Receptor-Interacting Protein 3 and Parkin, Essential Molecules for Necroptosis, in Breast Cancer
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Photoprotective effects of topical ginseng leaf extract using Ultraflo L against UVB-induced skin damage in hairless mice
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Isorhamnetin Protects Human Keratinocytes against Ultraviolet B-Induced Cell Damage
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Actinidia polygama Water Extract (APWE) Protects Against UVB-Induced Photoaging via MAPK/AP-1 and TGFβ-Smad Pathway
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NB-UVB Induces Melanocytic Differentiation of Human Hair Follicle Neural Crest Stem Cells
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UCI(KEPA) : I410-ECN-0101-2016-510-002777173