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Mitochondria in Cancer Energy Metabolism : Culprits or Bystanders?
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Type
Academic journal
Author
Aekyong Kim (Catholic University of Daegu)
Journal
The Korean Society Of Toxicology Toxicological Research Vol.31 No.4 KCI Accredited Journals SCOPUS
Published
2015.12
Pages
323 - 330 (8page)

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Mitochondria in Cancer Energy Metabolism : Culprits or Bystanders?
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Cancer is a disease characterized by uncontrolled growth. Metabolic demands to sustain rapid proliferation must be compelling since aerobic glycolysis is the first as well as the most commonly shared characteristic of cancer. During the last decade, the significance of metabolic reprogramming of cancer has been at the center of attention. Nonetheless, despite all the knowledge gained on cancer biology, the field is not able to reach agreement on the issue of mitochondria: Are damaged mitochondria the cause for aerobic glycolysis in cancer? Warburg proposed the damaged mitochondria theory over 80 years ago; the field has been testing the theory equally long. In this review, we will discuss alterations in metabolic fluxes of cancer cells, and provide an opinion on the damaged mitochondria theory.
#Cancer #Mitochondria #Metabolism #Aerobic glycolysis #Glutaminolysis #Anaplerosis #Cataplerosis

Contents

INTRODUCTION
CLOSING REMARKS
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