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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2015.12
- 수록면
- 98 - 103 (6page)
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Hyperthermia is a type of cancer treatment in which body tissue is exposed to higher temperatures to damage and kill cancer cells. Minimally invasive treatment of solid tumors, especially in the human organs, remains clinically challenging, despite a variety of treatment modalities are available. In the present study a non-invasive selective heating of tumor by sparing the normal cells was investigated with experimental and numerical approaches. A cylindrical tissuemimicking tumor phantom gel was prepared for the selectivity test and a patient-specific simulation on real human anatomy model, which was reconstructed and segmented from computed tomography (CT) image, was used to determine the thermal distribution in liver tumor during radiofrequency (RF) heating. An RF electrode at 13.56 MHz frequency was used as the heat source for the experiment and simulations were performed with the aid of the multiphysiscs simulation platform Sim4Life. Experimental results depict the selective heating of the tumor and the same was validated with that of simulations. A high temperature rise was achieved for the liver tumor from the patientspecific simulation which elucidated the high energy absorption of malignant tissue compared to the normal surrounding tissues and thereby regional heating of RF hyperthermia was demonstrated in a real human anatomy. The study also exhibits the effect of electrodes with different sizes and power modulation, which paves a way for effective treatment planning. The calculated thermal dose values depicts the damage of malignant tissues in the liver and no normal tissues were damaged during heating, which gives more realistic outcomes for clinical applications.
목차
Abstract
1. INTRODUCTION
2. MATERIALS AND METHODS
3. RESULTS AND DISCUSSION
4. CONCLUSION
REFERENCES
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UCI(KEPA) : I410-ECN-0101-2016-505-002171623