지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.20 No.3
- 발행연도
- 2015.9
- 수록면
- 153 - 161 (9page)
이용수
초록· 키워드
오류제보하기
Matrix metalloproteinases (MMPs) are crucial extracellular matrices degrading enzymes that have important roles in metastasis of cancer progression as well as other significant conditions such as oxidative stress and hepatic fibrosis. Marine plants are on the rise for their potential to provide natural products that exhibit remarkable health benefits. In this context, brown algae species have been of much interest in the pharmaceutical field with reported instances of isolation of bioactive compounds against tumor growth and MMP activity. In this study, eight different brown algae species were harvested, and their extracts were compared in regard to their anti-MMP effects. According to gelatin zymography results, Ecklonia cava, Ecklonia bicyclis, and Ishige okamurae showed higher inhibitory effects than the other samples on MMP-2 and -9 activity at the concentrations of 10, 50, and 100 ?g/mL. However, only I. okamurae was able to regulate the MMP activity through the expression of MMP and tissue inhibitor of MMP observed by mRNA levels. Overall, brown algae species showed to be good sources for anti-MMP agents, while I. okamurae needs to be further studied for its potential to yield pharmaceutical molecules that can regulate MMP-activity through cellular pathways as well as enzymatic inhibition.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (23)
참고문헌 신청
[학술지(정기간행물)] - Jones JL / 1997 / Control of matrix metalloproteinase activity in cancer / J Pathol 183 : 377 ~ 379
[학술지(정기간행물)] - Shuman Moss LA / 2012 / Matrix metalloproteinases : changing roles in tumor progression and metastasis / Am J Pathol 181 : 1895 ~ 1899
[학술지(정기간행물)] - Egeblad M / 2002 / New functions for the matrix metalloproteinases in cancer progression / Nat Rev Cancer 2 : 161 ~ 174
[학술지(정기간행물)] - Bauvois B / 2012 / New facets of matrix metalloproteinases MMP-2 and MMP-9 as cell surface transducers : Outside-in signaling and relationship to tumor progression / Biochim Biophys Acta 1825 : 29 ~ 36
[학술지(정기간행물)] - Overall CM / 2002 / Strategies for MMP inhibition in cancer : innovations for the post-trial era / Nat Rev Cancer 2 : 657 ~ 672
[학술지(정기간행물)] - Shuman Moss LA / 2012 / Matrix metalloproteinases : changing roles in tumor progression and metastasis / Am J Pathol 181 : 1895 ~ 1899
[학술지(정기간행물)] - Egeblad M / 2002 / New functions for the matrix metalloproteinases in cancer progression / Nat Rev Cancer 2 : 161 ~ 174
[학술지(정기간행물)] - Bauvois B / 2012 / New facets of matrix metalloproteinases MMP-2 and MMP-9 as cell surface transducers : Outside-in signaling and relationship to tumor progression / Biochim Biophys Acta 1825 : 29 ~ 36
[학술지(정기간행물)] - Overall CM / 2002 / Strategies for MMP inhibition in cancer : innovations for the post-trial era / Nat Rev Cancer 2 : 657 ~ 672
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UCI(KEPA) : I410-ECN-0101-2016-594-001972781