지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.9
- 수록면
- 135 - 143 (9page)
이용수
초록· 키워드
오류제보하기
Electrocardiogram measures the electric impulses generated by the heart during its cycle. Recently genome-wide association studies on electrocardiogram traits revealed many relevant genetic loci. Therefore, these findings need to be validated and investigated to determine the underlying mechanisms using mouse models. Invasive radiotelemetry has been widely used to record the electrocardiogram in mice because it has several advantages over non-invasive measurements. However, radiotelemetry is expensive and requires complicated surgery. On the other hand, a non-invasive method using 3 electrodes (one for earth) for lead II is easy to establish and allows for rapid measurement. In this study, eleven mice were measured with this non-invasive method and no statistical difference among them was found in any ECG measurements. In addition, repeat measurement in the same mouse was performed in 9 sets of experiment and the results indicated that non-invasive method was reliable for reproducibility. Further it was shown that measurements for 1, 5, 10, and 15 minutes were not different so that a short recording such as 5 minutes was enough to estimate the ECG values including heart rate. Further this method was validated by measuring the ECG of Balb/c and FVB that were previously shown to differ in ECG values by radiotelemetry. Significant differences were found in heart rate, PR interval and corrected QT interval between these mouse strains. This study partially proved that non-invasive method also could provide the accuracy and reproducibility. Based on these results, the non-invasive ECG recordings of lead II is recommended as a useful method for quick test in mouse model.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (28)
참고문헌 신청
[학술지(정기간행물)] - Bigger JT Jr / 1992 / Frequency domain measures of heart period variability and mortality after myocardial infarction / Circulation 85 : 164 ~ 171
[학술지(정기간행물)] - Bruell JH / 1962 / Strain and sex differences in serum cholesterol levels of mice / Science 135 : 1071 ~ 1072
[학술지(정기간행물)] - de Bruyne MC / 1999 / Prolonged QT interval predicts cardiac and all-cause mortality in the elderly. The Rotterdam Study / Eur Heart J 20 : 278 ~ 284
[학술지(정기간행물)] - Erhardt W / 1984 / A comparative study with various anesthetics in mice (pentobarbitone, ketamine-xylazine, carfentanyl-etomidate) / Res Exp Med 184 : 159 ~ 169
[학술지(정기간행물)] - Gao S / 2011 / Echocardiography in mice / Curr Protoc Mouse Biol 1 : 71 ~ 83
[학술지(정기간행물)] - Bruell JH / 1962 / Strain and sex differences in serum cholesterol levels of mice / Science 135 : 1071 ~ 1072
[학술지(정기간행물)] - de Bruyne MC / 1999 / Prolonged QT interval predicts cardiac and all-cause mortality in the elderly. The Rotterdam Study / Eur Heart J 20 : 278 ~ 284
[학술지(정기간행물)] - Erhardt W / 1984 / A comparative study with various anesthetics in mice (pentobarbitone, ketamine-xylazine, carfentanyl-etomidate) / Res Exp Med 184 : 159 ~ 169
[학술지(정기간행물)] - Gao S / 2011 / Echocardiography in mice / Curr Protoc Mouse Biol 1 : 71 ~ 83
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UCI(KEPA) : I410-ECN-0101-2016-510-001968061