지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.89 No.2
- 발행연도
- 2015.7
- 수록면
- 74 - 80 (7page)
이용수
초록· 키워드
오류제보하기
Purpose: Overexpression of cortactin (CTTN) in human tumors has been proposed to result in increased cell migration and metastatic potential. Here, we determined the frequencies of CTTN g.-9101C＞T, g.-8748C＞T, and g.72C＞T polymorphisms in apparently healthy subjects and gastric cancer patients, respectively, and the influence of the CTTN polymorphisms on gastric cancer susceptibility.
Methods: Blood samples were collected from 267 patients and 533 controls. CTTN g.-8748C＞T and g.-9101C＞T polymorphisms were determined using polymerase chain reaction-restriction fragment length polymorphism; the g.72C＞T polymorphism was determined using the TaqMan method.
Results: Genotype frequencies of the CTTN g.-9101C＞T polymorphism were 97.5% (TT), 2.5% (TC), and 0% (CC) in the patient group,and 98.6% (TT), 1.4% (TC), and 0% (CC) in the control group. Genotype frequencies of the CTTN g.-8748C＞T polymorphism were 93.3% (TT), 6.8% (TC), and 0% (CC) in the patient group, and 94.2% (TT), 5.8% (TC), and 0% (CC) in the control group. Genotype frequencies of the CTTN g.72C＞T polymorphism were 82.4% (CC), 17.2% (CT), and 0.4% (TT) in the patient group, and 78.0% (CC), 20.1% (CT), and 1.9% (TT) in the control group. Genotype and allele frequencies of the CTTN g.-9101C＞T polymorphism differed significantly between the advanced gastric cancer and control groups. Patients with advanced gastric cancer, possessing the TC genotype, had a significantly poorer prognosis than the group with the TT genotype.
Conclusion: The CTTN g.-9101C＞T polymorphism might influence advanced gastric cancer susceptibility. However, the role of the CTTN g.-9101C＞T, g.-8748C＞T, and g.72C＞T polymorphisms requires careful interpretation and confirmation through larger studies.
Methods: Blood samples were collected from 267 patients and 533 controls. CTTN g.-8748C＞T and g.-9101C＞T polymorphisms were determined using polymerase chain reaction-restriction fragment length polymorphism; the g.72C＞T polymorphism was determined using the TaqMan method.
Results: Genotype frequencies of the CTTN g.-9101C＞T polymorphism were 97.5% (TT), 2.5% (TC), and 0% (CC) in the patient group,and 98.6% (TT), 1.4% (TC), and 0% (CC) in the control group. Genotype frequencies of the CTTN g.-8748C＞T polymorphism were 93.3% (TT), 6.8% (TC), and 0% (CC) in the patient group, and 94.2% (TT), 5.8% (TC), and 0% (CC) in the control group. Genotype frequencies of the CTTN g.72C＞T polymorphism were 82.4% (CC), 17.2% (CT), and 0.4% (TT) in the patient group, and 78.0% (CC), 20.1% (CT), and 1.9% (TT) in the control group. Genotype and allele frequencies of the CTTN g.-9101C＞T polymorphism differed significantly between the advanced gastric cancer and control groups. Patients with advanced gastric cancer, possessing the TC genotype, had a significantly poorer prognosis than the group with the TT genotype.
Conclusion: The CTTN g.-9101C＞T polymorphism might influence advanced gastric cancer susceptibility. However, the role of the CTTN g.-9101C＞T, g.-8748C＞T, and g.72C＞T polymorphisms requires careful interpretation and confirmation through larger studies.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (30)
참고문헌 신청
[학술지(정기간행물)] - 대한위암학회 정보전산위원회 / 2007 / 2004년 전국 위암 등록사업 결과 보고 / Journal of Gastric Cancer 7 (1) : 47 ~ 54
[학술지(정기간행물)] - Hartgrink HH. / 2009 / Gastric cancer / Lancet 374 : 477 ~ 490
[학술지(정기간행물)] - de Martel C. / 2013 / Gastric cancer : epidemiology and risk factors / Gastroenterol Clin North Am 42 : 219 ~ 240
[학술지(정기간행물)] - Wang XQ. / 2012 / Interaction between dietary factors and Helicobacter pylori infection in noncardia gastric cancer : a population-based case-control study in China / J Am Coll Nutr 31 : 375 ~ 384
[학술지(정기간행물)] - Songun I. / 1999 / Classification of gastric carcinoma using the Goseki system provides prognostic information additional to TNM staging / Cancer 85 : 2114 ~ 2118
[학술지(정기간행물)] - Hartgrink HH. / 2009 / Gastric cancer / Lancet 374 : 477 ~ 490
[학술지(정기간행물)] - de Martel C. / 2013 / Gastric cancer : epidemiology and risk factors / Gastroenterol Clin North Am 42 : 219 ~ 240
[학술지(정기간행물)] - Wang XQ. / 2012 / Interaction between dietary factors and Helicobacter pylori infection in noncardia gastric cancer : a population-based case-control study in China / J Am Coll Nutr 31 : 375 ~ 384
[학술지(정기간행물)] - Songun I. / 1999 / Classification of gastric carcinoma using the Goseki system provides prognostic information additional to TNM staging / Cancer 85 : 2114 ~ 2118
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UCI(KEPA) : I410-ECN-0101-2016-514-001722690