지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.8
- 수록면
- 207 - 218 (12page)
이용수
초록· 키워드
오류제보하기
Chronic virus infection leads to the functional impairment of dendritic cells (DCs) as well as T cells, limiting the clinical usefulness of DC-based therapeutic vaccine against chronic virus infection. Meanwhile, B cells have been known to maintain the ability to differentiate plasma cells producing antibodies even during chronic virus infection. Previously, α-galactosylceramide (αGC) and cognate peptide-loaded B cells were comparable to DCs in priming peptide-specific CD8<sup>+</sup> T cells as antigen presenting cells (APCs). Here, we investigated whether B cells activated by αGC can improve virus-specific T cell immune responses instead of DCs during chronic virus infection. We found that comparable to B cells isolated from na?ve mice, chronic B cells isolated from chronically infected mice with lymphocytic choriomeningitis virus (LCMV) clone 13 (CL13) after αGC-loading could activate CD1d-restricted invariant natural killer T (iNKT) cells to produce effector cytokines and upregulate co-stimulatory molecules in both na?ve and chronically infected mice. Similar to na?ve B cells, chronic B cells efficiently primed LCMV glycoprotein (GP) 33-41-specific P14 CD8<sup>+</sup> T cells in vivo, thereby allowing the proliferation of functional CD8<sup>+</sup> T cells. Importantly, when αGC and cognate epitope-loaded chronic B cells were transferred into chronically infected mice, the mice showed a significant increase in the population of epitope-specific CD8<sup>+</sup> T cells and the accelerated control of viremia. Therefore, our studies demonstrate that reciprocal activation between αGC-loaded chronic B cells and iNKT cells can strengthen virus-specific T cell immune responses, providing an effective regimen of autologous B cell-based therapeutic vaccine to treat chronic virus infection.
목차
등록된 정보가 없습니다.
참고문헌 (37)
참고문헌 신청
1. [학술지(정기간행물)] - Wherry, E. J. / 2003 / Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment / J. Virol 77 : 4911 ~ 4927
2. [학술지(정기간행물)] - Ha, S. J / 2008 / Manipulating both the inhibitory and stimulatory immune system towards the success of therapeutic vaccination against chronic viral infections / Immunol. Rev 223 : 317 ~ 333
3. [학술지(정기간행물)] - Virgin, H. W. / 2009 / Redefining chronic viral infection / Cell 138 : 30 ~ 50
4. [학술지(정기간행물)] - Zajac, A. J. / 1998 / Viral immune evasion due to persistence of activated T cells without effector function / J. Exp. Med 188 : 2205 ~ 2213
5. [학술지(정기간행물)] - Hyun-Tak Jin / 2011 / Mechanism of T cell exhaustion in a chronic environment / BMB Reports 44 (4) : 217 ~ 231
2. [학술지(정기간행물)] - Ha, S. J / 2008 / Manipulating both the inhibitory and stimulatory immune system towards the success of therapeutic vaccination against chronic viral infections / Immunol. Rev 223 : 317 ~ 333
3. [학술지(정기간행물)] - Virgin, H. W. / 2009 / Redefining chronic viral infection / Cell 138 : 30 ~ 50
4. [학술지(정기간행물)] - Zajac, A. J. / 1998 / Viral immune evasion due to persistence of activated T cells without effector function / J. Exp. Med 188 : 2205 ~ 2213
5. [학술지(정기간행물)] - Hyun-Tak Jin / 2011 / Mechanism of T cell exhaustion in a chronic environment / BMB Reports 44 (4) : 217 ~ 231
이 논문의 저자 정보
이 논문과 함께 이용한 논문
최근 본 자료
댓글(0)
0