지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 217 - 231 (15page)
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T cell exhaustion develops under conditions of antigenpersistence caused by infection with various chronic pathogens,such as human immunodeficiency virus (HIV) and mycobacterium tuberculosis (TB), or by the development of cancer.
T cell exhaustion is characterized by stepwise and progressive loss of T cell function, which is probably the main reason for the failed immunological control of chronic pathogens and cancers. Recent observations have detailed some of the intrinsic and extrinsic factors that influence the severity of T cell exhaustion. Duration and magnitude of antigenic activation of T cells might be associated with up-regulation of inhibitory receptors,which is a major intrinsic factor of T cell exhaustion.
Extrinsic factors might include the production of suppressive cytokines, T cell priming by either non-professional antigenpresenting cells (APCs) or tolerogenic dendritic cells (DCs),and alteration of regulatory T (Treg) cells. Further investigation of the cellular and molecular processes behind the development of T cell exhaustion can reveal therapeutic targets and strategies for the treatment of chronic infections and cancers.
Here, we report the properties and the mechanisms of T cell exhaustion in a chronic environment. [BMB reports 2011;44(4): 217-231]
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참고문헌 (26)
참고문헌 신청
[학술지(정기간행물)]
Ahmadzadeh, M / 2009 / Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired / Blood 114 : 1537 ~ 1544
Anichini, A / 2004 / The paradox of T-cell-mediated antitumor immunity in spite of poor clinical outcome in human melanoma / Cancer Immunol. Immunother 53 : 855 ~ 864
Badovinac, V. P / 2002 / CD8(+) T-cell homeostasis after infection: setting the 'curve' / icrobes Infect 4 : 441 ~ 447
Barber, D. L / 2006 / Restoring function in exhausted CD8 T cells during chronic viral infection / Nature 439 : 682 ~ 687
Ahmadzadeh, M / 2009 / Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired / Blood 114 : 1537 ~ 1544
Anichini, A / 2004 / The paradox of T-cell-mediated antitumor immunity in spite of poor clinical outcome in human melanoma / Cancer Immunol. Immunother 53 : 855 ~ 864
Badovinac, V. P / 2002 / CD8(+) T-cell homeostasis after infection: setting the 'curve' / icrobes Infect 4 : 441 ~ 447
Barber, D. L / 2006 / Restoring function in exhausted CD8 T cells during chronic viral infection / Nature 439 : 682 ~ 687
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