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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.10
- 수록면
- 227 - 244 (18page)
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초록· 키워드
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MicroRNAs (miRNAs) are small noncoding RNA molecules that negatively regulate gene expression via degradation or translational repression of their target messenger RNAs (mRNAs). Recent studies have clearly demonstrated that miRNAs play critical roles in several biologic processes, including cell cycle, differentiation, cell development, cell growth, and apoptosis and that miRNAs are highly expressed in regulatory T (Treg) cells and a wide range of miRNAs are involved in the regulation of immunity and in the prevention of autoimmunity. It has been increasingly reported that miRNAs are associated with various human diseases like autoimmune disease, skin disease, neurological disease and psychiatric disease. Recently, the identification of miRNAs in skin has added a new dimension in the regulatory network and attracted significant interest in this novel layer of gene regulation. Although miRNA research in the field of dermatology is still relatively new, miRNAs have been the subject of much dermatological interest in skin morphogenesis and in regulating angiogenesis. In addition, miRNAs are moving rapidly center stage as key regulators of neuronal development and function in addition to important contributions to neurodegenerative disorder. Moreover, there is now compelling evidence that dysregulation of miRNA networks is implicated in the development and onset of human neruodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, Tourette's syndrome, Down syndrome, depression and schizophrenia. In this review, I briefly summarize the current studies about the roles of miRNAs in various autoimmune diseases, skin diseases, psychoneurological disorders and mental stress.
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참고문헌 (112)
참고문헌 신청
Lee RC / 1993 / The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14 / Cell 75:843~854
Wightman B / 1993 / Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans / Cell 75:855~862
O'Connell RM / 2010 / Physiological and pathological roles of microRNAs in the immune system / Nat Rev Immunol 10:111~122
Bartel DP / 2004 / MicroRNAs: Genomics, biogenesis, mechanims, and funtion / Cell 116:281~297
Tili E / 2008 / Expression and function of microRNAs in immune cells during normal or disease state / Int J Med 5:73~79
Wightman B / 1993 / Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans / Cell 75:855~862
O'Connell RM / 2010 / Physiological and pathological roles of microRNAs in the immune system / Nat Rev Immunol 10:111~122
Bartel DP / 2004 / MicroRNAs: Genomics, biogenesis, mechanims, and funtion / Cell 116:281~297
Tili E / 2008 / Expression and function of microRNAs in immune cells during normal or disease state / Int J Med 5:73~79
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