지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.2
- 수록면
- 11 - 41 (31page)
이용수
초록· 키워드
오류제보하기
The discovery of microRNA (miRNA) is one of the major scientific breakthroughs in recent years and has revolutionized current cell biology and medical science. miRNAs are small (19~25nt) noncoding RNA molecules that post-transcriptionally regulate gene expression by targeting the 3' untranslated region (3'UTR) of specific messenger RNAs (mRNAs) for degradation of translation repression. Genetic ablation of the miRNA machinery, as well as loss or degradation of certain individual miRNAs, severely compromises immune development and response, and can lead to immune disorders. Several sophisticated regulatory mechanisms are used to maintain immune homeostasis. Regulatory T (Treg) cells are essential for maintaining peripheral tolerance, preventing autoimmune diseases and limiting chronic inflammatory diseases. Recent publications have provided compelling evidence that miRNAs are highly expressed in Treg cells, that the expression of Foxp3 is controlled by miRNAs and that a range of miRNAs are involved in the regulation of immunity. A large number of studies have reported links between alterations of miRNA homeostasis and pathological conditions such as cancer, cardiovascular disease and diabetes, as well as psychiatric and neurological diseases. Although it is still unclear how miRNA controls Treg cell development and function, recent studies certainly indicate that this topic will be the subject of further research. The specific circulating miRNA species may also be useful for the diagnosis, classification, prognosis of diseases and prediction of the therapeutic response. An explosive literature has focussed on the role of miRNA. In this review, I briefly summarize the current studies about the role of miRNAs in Treg cells and in the regulation of the innate and adaptive immune response. I also review the explosive current studies about clinical application of miRNA.
목차
등록된 정보가 없습니다.
참고문헌 (214)
참고문헌 신청
Gershon RK / 1971 / Infectious immunological tolerance / Immunology 21:903~914
Gershon RK / 1972 / Suppressor T cells / J Immunol 108:586~590
Ha TY / 1973 / Role of the thymus in tolerance. X. “Suppressor” activity of antigen-stimulated rat thymocytes transferred to normal recipients / J Immunol 110:1290~1299
Ha TY / 1974 / The thymic suppressor cell. I. Separation of subpopulations with suppressor activity / J Exp Med 139:13~23
Ha TY / 1974 / The thymic suppre-sor cell. II. Metabolic requirements of suppressor activity / Immunol Commun 3:351~359
Gershon RK / 1972 / Suppressor T cells / J Immunol 108:586~590
Ha TY / 1973 / Role of the thymus in tolerance. X. “Suppressor” activity of antigen-stimulated rat thymocytes transferred to normal recipients / J Immunol 110:1290~1299
Ha TY / 1974 / The thymic suppressor cell. I. Separation of subpopulations with suppressor activity / J Exp Med 139:13~23
Ha TY / 1974 / The thymic suppre-sor cell. II. Metabolic requirements of suppressor activity / Immunol Commun 3:351~359
이 논문의 저자 정보
이 논문과 함께 이용한 논문
최근 본 자료
댓글(0)
0