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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.8
- 수록면
- 115 - 121 (7page)
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초록· 키워드
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Natural killer (NK) cells play key roles in innate and adaptive immune defenses. NK cell responses are mediated by two major mechanisms: the direct cytolysis of target cells, and immune regulation by production of various cytokines. Many previous reports show that the complex NK cell activation process requires de novo gene expression regulated at both transcriptional and post-transcriptional levels. Specialized un-translated regions (UTR) of mRNAs are the main mechanisms of post-transcriptional regulation. Analysis of posttranscriptional regulation is needed to clearly understand NK cell biology and, furthermore, harness the power of NK cells for therapeutic aims. This review summarizes the current understanding of mRNA metabolism during NK cell activation, focusing primarily on post-transcriptional regulation.
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등록된 정보가 없습니다.
참고문헌 (44)
참고문헌 신청
1. [학술지(정기간행물)] - Vély F / 2005 / Natural killer cell receptor signaling pathway in mammals / Sci STKE 12
2. [학술지(정기간행물)] - Shu Y / 2004 / Transcription, translation, degradation,and circadian clock / Biochem Biophys Res Commun 321 : 1 ~ 6
3. [학술지(정기간행물)] - Allgayer H / 2006 / Regulation and clinical significance of urokinase-receptor (u-PAR), an invasion-related molecule / Z Gastroenterol 44 : 503 ~ 511
4. [학술지(정기간행물)] - Shetty S / 2005 / Protein synthesis and urokinase mRNA metabolism / Mol Cell Biochem 271 : 13 ~ 22
5. [학술지(정기간행물)] - Velusamy T / 2008 / Posttranscriptional regulation of urokinase receptor expression by heterogeneous nuclear ribonuclear protein C / Biochemistry 47 : 6508 ~ 6517
2. [학술지(정기간행물)] - Shu Y / 2004 / Transcription, translation, degradation,and circadian clock / Biochem Biophys Res Commun 321 : 1 ~ 6
3. [학술지(정기간행물)] - Allgayer H / 2006 / Regulation and clinical significance of urokinase-receptor (u-PAR), an invasion-related molecule / Z Gastroenterol 44 : 503 ~ 511
4. [학술지(정기간행물)] - Shetty S / 2005 / Protein synthesis and urokinase mRNA metabolism / Mol Cell Biochem 271 : 13 ~ 22
5. [학술지(정기간행물)] - Velusamy T / 2008 / Posttranscriptional regulation of urokinase receptor expression by heterogeneous nuclear ribonuclear protein C / Biochemistry 47 : 6508 ~ 6517
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