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논문 기본 정보

자료유형
학술저널
저자정보
Moa Sa (Seoul National University College of Medicine) Chung-Gyu Park (Seoul National University College of Medicine) Eung-Soo Hwang (Seoul National University College of Medicine)
저널정보
대한바이러스학회 JOURNAL OF BACTERIOLOGY AND VIROLOGY Journal of Bacteriology and Virology 제44권 제1호
발행연도
2014.3
수록면
75 - 83 (9page)

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All xenografts from pigs impose infection risk by porcine endogenous retrovirus (PERV). The purpose of this study was to investigate the env constructs with the comparison of the ratio of the competent form to the defective one of env in subtypes, PERV-A, PERV-B and PERV-C in different pig breeds. The results of PCR amplification of env represented that all env subtypes had more than two defective forms which cannot bind to host cells due to the absence of binding regions of env in miniature pigs, SNU and PWG, and farm pig breeds, Duroc, Yorkshire and Landrace. In addition, comparing the full sequences with the defective ones in three subtypes demonstrated that the present percentages of env sequences in defective PERV-A, PERV-B and PERV-C were approximately 50%, 38~45% and 4~11%, respectively, in SNU and PWG pigs whereas PERV-A and PERV-B occupied around 40 to 60% but PERV-C was not detected in farm pigs. Quantitative real-time PCR assays with primers and probes targeted to proline-rich region (PRR) of each env subtype were done to measure the copy numbers of each env subtype. When the reference was set with copy number of PERV-A, the ratio of those of PERV-B and PERV-C to the reference were 1.5 to 6.0 folds high in SNU and PWG pigs while 1.0 or less in farm pigs. These contradictory results of PERV-C constructs and copy numbers in SNU pigs suggests that many truncated or short defective sequences of PERV-C might be present in them.
#Xenotransplantation #Porcine endogenous retrovirus #Subtype #Proviral load #Genome construct

목차

INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSIONS
REFERENCES

참고문헌 (25)

참고문헌 신청
1. [학술지(정기간행물)] - Martignat L. / 1998 / Detection of porcine endogenous retrovirus : possible involvement in pig islet xenotransplantation / Diabetes Metab 24 : 434 ~ 441 google schola 2. [학술지(정기간행물)] - Denner J. / 2012 / Infection barriers to successful xenotransplantation focusing on porcine endogenous retroviruses / Clin Microbiol Rev 25 : 318 ~ 343 google schola 3. [학술지(정기간행물)] - Schmidt P. / 2004 / Possible transmission of zoonoses in xenotransplantation : porcine endogenous retroviruses(PERVs)from an immunological point of view / Acta Vet Scand Suppl 99 : 27 ~ 34 google schola 4. [학술지(정기간행물)] - Frühauf JH. / 2009 / Porcine endogenous retrovirus released by a bioartificial liver infects primary human cells / Liver Int 29 : 1553 ~ 1561 google schola 5. [학술지(정기간행물)] - Martin U. / 1998 / Expression of pig endogenous retrovirus by primary porcine endothelial cells and infection of human cells / Lancet 352 : 692 ~ 694 google schola

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