지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.6
- 수록면
- 126 - 131 (6page)
이용수
초록· 키워드
오류제보하기
Naturally occurring reoviruses are live replication-proficient viruses specifically infecting human cancer cell while sparing normal counterpart. Since the discovery of reoviruses in 1950s, reoviruses have shown various degrees of safety and efficacy in pre-clinical or clinical application for human anti-cancer therapeutics. I have recently shown that cellular tumor suppressor genes, such as p53, ATM (Ataxia telangiectasia mutated), and RB (Retinoblastoma associated), are important in determining reoviral oncotropism. Thus, it is interesting to examine whether the aberrancy of c-Myc expression, whose normal function also plays an important role in the maintenance of genomic integrity, could affect reoviral oncolytic tropism. Hs68 cells are non-tumorigenic normal cells and resistant to reoviral cytopathic effects. Importantly, I found that c-Myc overexpression in human HS68 cells effectively induced reovirus cytophatic effects compared to mock expressed cells as shown by the typical reoviral cytophathology and an increased level of caspase-3 activity. Taken together, overexpression of c-Myc could play an important role in determining reoviral oncolytic tropism.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (21)
참고문헌 신청
[단행본] - Tyler KL / 2001 / Fields Virology / Lippincott-Raven : 1729 ~ 1745
[학술지(정기간행물)] - Ramig RF / 1977 / Genome RNAs and polypeptides of reovirus serotypes 1, 2, and 3 / J Virol 22 : 726 ~ 733
[학술지(정기간행물)] - Stoeckel J / 2006 / Drug evaluation: Reolysin--wildtype reovirus as a cancer therapeutic / Curr Opin Mol Ther 8 : 249 ~ 260
[학술지(정기간행물)] - 김만복 / 2015 / Replicating poxviruses for human cancer therapy / The Journal of Microbiology 53 (4) : 209 ~ 218
[학술지(정기간행물)] - Roberts MS / 2006 / Naturally oncolytic viruses / Curr Opin Mol Ther 8 : 314 ~ 321
[학술지(정기간행물)] - Ramig RF / 1977 / Genome RNAs and polypeptides of reovirus serotypes 1, 2, and 3 / J Virol 22 : 726 ~ 733
[학술지(정기간행물)] - Stoeckel J / 2006 / Drug evaluation: Reolysin--wildtype reovirus as a cancer therapeutic / Curr Opin Mol Ther 8 : 249 ~ 260
[학술지(정기간행물)] - 김만복 / 2015 / Replicating poxviruses for human cancer therapy / The Journal of Microbiology 53 (4) : 209 ~ 218
[학술지(정기간행물)] - Roberts MS / 2006 / Naturally oncolytic viruses / Curr Opin Mol Ther 8 : 314 ~ 321
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
The Trend in the Development of Oncolytic Virus Therapy
대한의생명과학회지
2019 .09
-
Cancer-selective Mechanisms of Oncolytic Viruses
보건학논집
2015 .03
-
Molecular and Cytogenetic Studies in a Child with Burkitt Lymphoma and Ataxia-Telangiectasia Syndrome Harboring MYC Overexpression and Partial Trisomy 8
Annals of Laboratory Medicine
2018 .01
-
Relationship of Amplification and Expression of the C-MYC Gene with Survival among Gastric Cancer Patients
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Gemcitabine Inhibits the Progression of Pancreatic Cancer by Restraining the WTAP/MYC Chain in an m6A-Dependent Manner
Cancer Research and Treatment
2024 .01
-
N-myc Downstream Regulated Gene 1 Promotes Adipocyte Differentiation in Endothelial Cells of Infantile Hemangioma
Annals of Dermatology
2023 .06
-
Malignant transformation in a Breast Adenomyoepithelioma Caused by Amplification of c-MYC: A Common pathway to Cancer in a Rare Entity
Journal of Breast Cancer
2020 .01
-
CD5+ follicular lymphoma rapidly transformed to high-grade B-cell lymphoma with double-hit: from BCL2 to MYC disruption
Blood Research
2023 .03
-
Erratum: c-Myc-Induced Long Non-Coding RNA Small Nucleolar RNA Host Gene 7 Regulates Glycolysis in Breast Cancer
Journal of Breast Cancer
2020 .01
-
β-carotene Inhibits Expression of c-Myc and Cyclin E in Helicobacter pylori-infected Gastric Epithelial Cells
대한암예방학회지
2019 .01
-
Long Non-coding RNA HOTAIR Expression in Diffuse Large B-Cell Lymphoma: In Relation to Polycomb Repressive Complex Pathway Proteins and H3K27 Trimethylation
Journal of Pathology and Translational Medicine
2016 .01
-
Activation of NF-κB and AP-1 Mediates Hyperproliferation by Inducing β-Catenin and c-Myc in Helicobacter pylori-Infected Gastric Epithelial Cells
Yonsei Medical Journal
2016 .01
-
Early Experience of Oncolytic Virus Injection Combined with Sorafenib in a Patient with Advanced Hepatocellular Carcinoma and Portal Vein Thrombosis
Journal of Liver Cancer
2020 .01
-
Contradictory Relationships between Cancer and Normal Cells and Implications for Anti-cancer Therapy
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
유방암 줄기세포 개념 및 제한점
의생명과학
2018 .01
-
Immune Correlates of Resistance to Trichinella spiralis Reinfection in Mice
Parasites, Hosts and Diseases
2016 .10
-
Clonal Expansion of Allergen-specific CD4+ T Cell in the Lung in the Absence of Lymph Nodes
Immune Network
2017 .06
-
How Can We Treat Cancer Disease Not Cancer Cells?
Cancer Research and Treatment
2017 .01
-
Induction of Apoptosis and Cell Cycle Arrest by Dorema Glabrum Root Extracts in a Gastric Adenocarcinoma (AGS) Cell Line
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Germline risk of patients with multiple Lynch syndrome related cancers and genomic comparison of multiple tumors from an individual
대한임상종양학회 학술대회지
2021 .06
이 논문의 저자 정보
최근 본 자료
댓글(0)
0