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학술저널
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대한바이러스학회 JOURNAL OF BACTERIOLOGY AND VIROLOGY 大韓바이러스學會誌 제23권 제1호
발행연도
1993.6
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17 - 26 (10page)

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Although transfusion-transmitted infections are colmpicated by a variety of microorganisms, one of the most frequent posttransfusion infections may be hepatitis caused by either hepatitis B virus (HBV) or non-A, non-B hepatitis agent(hepatitis C virus). In this study, prevalence of HBsAg, anti HCV, nontreponemal antibody to VDRL antigen and nonspecific antibody against HIV-1 in blood samples of 52,813 donors was investigated. In addition, significance of cut-off value(> 65 units) of serum alanine transaminase(ALT) in HBsAg and anti- HCV positive donors were evaluated, and the distribution of ABO groups and Rho(D) antigen wers investigated. The prevalence of HBsAg, anti-HCV and HBsAg+anti-HCV positive donors were 5.9%, 0.6% and 0.6%, respectively. The incidence of antibody positivity to HIV 1 by ELISA test using AIDS virus antigen was 0.14%(73/52, 813), but all were negative by confirmed test by Western blots. The consistency of the increase of serum ALT level over cut-off value (>65 units) in HBsAg positive donors, anti-HCV positive donors and HBsAg+anti HCV positive donors were 13.5% (421/ 3, 177), 18.1%(54/297) and 10.0%(34/388), respectively. The incidence of nontreponemal antibody to VDRL antigen was 0.34 % (175/52,813). The highest frequency of ABO blood groups of donors blood was A type(33.6%), followed by B (27.6%), 0(27.2%) and AB(11.3%), and most donors(99.7 %) were positive for Rho(D) antigen. These results indicate that to minimize the posttransfusion infections all samples of blood from donation should be tested for HBsAg and anti-HCV or other markers of HCV, anti-VDRL and anti -HIV-1 antibodies.

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