지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Rosiglitazone metabolites in rat plasma were analyzed after intraperitoneal and oral administration to rats. Seven metabolites (M1-M7) were detected in rat plasma (IP and PO), and the structures were confirmed using liquid chromatography-triple time of flight (TOF) mass spectrometry; as a result, the most abundant metabolite was M5, a de-methylated rosiglitazone. Other minor in vivo metabolites were driven from monooxygenation and demethylation (M2), thiazolidinedione ring-opening (M1, M3), mono-oxygenation (M4, M7), and mono-oxygenation followed by sulfation (M6). Among them, M1 was found to be a 3-{p-[2-(N-methyl-N-2-pyridylamino)ethoxy]phenyl}-2-(methylsulfinyl)propionamide, which is a novel metabolite of rosiglitazone. There was no significant difference in the metabolic profiles resulting from the two administrations. The findings of this study provide the first comparison of circulating metabolite profiles of rosiglitazone in rat after IP and PO administration and a novel metabolite of rosiglitazone in rat plasma.
목차
Abstract
1. Introduction
2. Experimental
3. Results and Discussion
4. Conclusions
References
참고문헌 (11)
참고문헌 신청
1. [학술지(정기간행물)] - J. M. Lehmann / 1995 / / J. Biol. Chem 270 (22) : 12953 ~ 12956
2. [학술지(정기간행물)] - A. R. Saltiel / 1996 / / Diabetes 45 (12) : 1661 ~ 1669
3. [학술지(정기간행물)] - J. Kohlroser / 2000 / / Am. J. Gastroenterol 95 (1) : 272 ~ 276
4. [학술지(정기간행물)] - K. V. N. Menon / 2001 / / Am. J. Gastroenterol 96 (5) : 1631 ~ 1634
5. [학술지(정기간행물)] - R. Alvarez-Sanchez / 2006 / / Chem. Res. Toxicol 19 (8) : 1106 ~ 1116
2. [학술지(정기간행물)] - A. R. Saltiel / 1996 / / Diabetes 45 (12) : 1661 ~ 1669
3. [학술지(정기간행물)] - J. Kohlroser / 2000 / / Am. J. Gastroenterol 95 (1) : 272 ~ 276
4. [학술지(정기간행물)] - K. V. N. Menon / 2001 / / Am. J. Gastroenterol 96 (5) : 1631 ~ 1634
5. [학술지(정기간행물)] - R. Alvarez-Sanchez / 2006 / / Chem. Res. Toxicol 19 (8) : 1106 ~ 1116
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UCI(KEPA) : I410-ECN-0101-2016-433-001461012