지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.20 No.1
- 발행연도
- 2015.3
- 수록면
- 43 - 51 (9page)
이용수
초록· 키워드
오류제보하기
ε-Polylysine (EPL) is used as a natural preservative in food. However, few studies have been conducted to assess the beneficial functions of dietary EPL. The purpose of this study was to elucidate the mechanism underlying the inhibition of neutral and acidic sterol absorption and hepatic enzyme activity-related fatty acid biosynthesis following EPL intake. EPL digest prepared using an in vitro digestion model had lower lipase activity and micellar lipid solubility and higher bile acid binding capacity than casein digest. Male Wistar rats were fed an AIN-93G diet containing 1% (wt/wt) EPL or L-lysine. After 4 weeks of feeding these diets, the marked decrease in serum and liver triacylglycerol contents by the EPL diet was partly attributed to increased fecal fatty acid excretion. The activities of hepatic acetyl-coenzyme A carboxylase and glucose-6-phosphate dehydrogenase, which are key enzymes of fatty acid biosynthesis, were enhanced in rats fed EPL diet. The increased fatty acid biosynthesis activity due to dietary EPL may be prevented by the enhancement of fecal fatty acid excretion. The hypocholesterolemic effect of EPL was mediated by increased fecal neutral and acidic sterol excretions due to the EPL digest suppressing micellar lipid solubility and high bile acid binding capacity. These results show that dietary EPL has beneficial effects that could help prevent lifestyle-related diseases such as hyperlipidemia and atherosclerosis.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
CONCLUSION
REFERENCES
참고문헌 (50)
참고문헌 신청
1. [학술지(정기간행물)] - Knopp RH / 2008 / Comprehensive lipid management versus aggressive lowdensity lipoprotein lowering to reduce cardiovascular risk / Am J Cardiol 101 : 48B ~ 57B
2. [학술지(정기간행물)] - Osler M / 2002 / Food intake patterns and risk of coronary heart disease : a prospective cohort study examining the use of traditional scoring techniques / Eur J Clin Nutr 56 : 568 ~ 574
3. [학술지(정기간행물)] - Hosomi R / 2011 / Fish protein decreases serum cholesterol in rats by inhibition of cholesterol and bile acid absorption / J Food Sci 76 : H116 ~ H121
4. [학술지(정기간행물)] - Nagaoka S / 1999 / Soy protein peptic hydrolysate with bound phospholipids decreases micellar solubility and cholesterol absorption in rats and caco-2 cells / J Nutr 129 : 1725 ~ 1730
5. [학술지(정기간행물)] - Nagata Y / 1982 / Studies on the mechanism of antihypercholesterolemic action of soy protein and soy protein-type amino acid mixtures in relation to the casein counterparts in rats / J Nutr 112 : 1614 ~ 1625
2. [학술지(정기간행물)] - Osler M / 2002 / Food intake patterns and risk of coronary heart disease : a prospective cohort study examining the use of traditional scoring techniques / Eur J Clin Nutr 56 : 568 ~ 574
3. [학술지(정기간행물)] - Hosomi R / 2011 / Fish protein decreases serum cholesterol in rats by inhibition of cholesterol and bile acid absorption / J Food Sci 76 : H116 ~ H121
4. [학술지(정기간행물)] - Nagaoka S / 1999 / Soy protein peptic hydrolysate with bound phospholipids decreases micellar solubility and cholesterol absorption in rats and caco-2 cells / J Nutr 129 : 1725 ~ 1730
5. [학술지(정기간행물)] - Nagata Y / 1982 / Studies on the mechanism of antihypercholesterolemic action of soy protein and soy protein-type amino acid mixtures in relation to the casein counterparts in rats / J Nutr 112 : 1614 ~ 1625
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UCI(KEPA) : I410-ECN-0101-2016-594-001353420