Purpose: This study was conducted to explore the meaning of failure experience of weight loss in obese highschool girls. Methods: Data were collected through focus group interviews with seven female students in July, 2013. The collected data were analyzed based on the six-step theme analysis method suggested by Braun & Clarke to describe the meaning level of repeated topics or patterns. Results: The finding was classified into eight themes: ‘Not men, not women, gender of the third, an obese person’, ‘a feeling of being an inferior person’, ‘Gaze of others influence my everyday life’, ‘wounded heart by significant others’, ‘Binge, regret, and the vicious cycle of fasting’, ‘rationalizing failure’, ‘not blaming others but myself’, ‘Diet that can not give up’. Conclusion: The findings indicate that health education teachers should provide the education and intervention programs to effectively manage stress and to establish positive self-image for obese highschool girls.