지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.12
- 수록면
- 432 - 436 (5page)
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초록· 키워드
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We investigated antioxidative activity of the ethanol extracts of leaves of Cornus walteri Wanger (CWE) by treated enzyme in human dermal fibroblast (HDFs) irradiated by UVB. We examined the in vitro chemical and cellular antioxidant activities of CWE in HDFs. We employed scavenging assay for the 1,1-diphenyl-2,5-picrylhydrazyl (DPPH) radicals and cellular antioxidative activity of CWE, and we was investigated in H₂O₂-treated or UVB-irradiated HDFs. The CWE effectively scavenged DPPH radicals (IC<SUB>50</SUB> 7.03± 0.4 μg/mL) when compared to the scavenging activities of Lascorbic acid (IC<SUB>50</SUB><SUB></SUB> 4.69±0.3 μg/mL). CWE reduced UVBinduced cellular damage in HS68 cells by MTT assay and inhibited intracellular ROS generation in dose-dependent manner. In addition, CWE also attenuated the elevated levels of 8-isoprostane resulting from UVB-mediated oxidative stress. Collectively, these results suggest that CWE could be a new potential candidate as antioxidant against UVB-induced oxidative stress in HDFs.
목차
Abstract
1. INTRODUCTION
2. MATERIALS AND METHOD
3. RESULTS AND DISCUSSION
4. CONCLUSION
REFERENCES
참고문헌 (23)
참고문헌 신청
1. [학술지(정기간행물)] - Matz H. / 2007 / UV light and its interaction with cutaneous receptors / Dermatol. Clin 25 : 633 ~ 641
2. [단행본] - Bryce, G. F. / 1993 / The effects of UV radiation on skin connective tissue, in oxidative stress in dermatology / Marcel Dekker, Inc : 105 ~ 125
3. [학술지(정기간행물)] - Kang S. / 2005 / Inflammation and extracellular matrix degradation mediated by activated transcription factors nuclear factorkappa B and activator protein-1 in inflammatory acne lesions in vivo / Am. J. Pathol 166 : 1691 ~ 1699
4. [학술지(정기간행물)] - Matsumura Y. / 2004 / Toxic effects of ultraviolet radiation on the skin / Toxicol. Appl. Pharmacol 195 : 298 ~ 308
5. [학술지(정기간행물)] - Halliwell B. / 1991 / DNA damage by oxygenderived species. Its mechanism and measurement in mammalian systems / FEBS Lett 281 : 9 ~ 19
2. [단행본] - Bryce, G. F. / 1993 / The effects of UV radiation on skin connective tissue, in oxidative stress in dermatology / Marcel Dekker, Inc : 105 ~ 125
3. [학술지(정기간행물)] - Kang S. / 2005 / Inflammation and extracellular matrix degradation mediated by activated transcription factors nuclear factorkappa B and activator protein-1 in inflammatory acne lesions in vivo / Am. J. Pathol 166 : 1691 ~ 1699
4. [학술지(정기간행물)] - Matsumura Y. / 2004 / Toxic effects of ultraviolet radiation on the skin / Toxicol. Appl. Pharmacol 195 : 298 ~ 308
5. [학술지(정기간행물)] - Halliwell B. / 1991 / DNA damage by oxygenderived species. Its mechanism and measurement in mammalian systems / FEBS Lett 281 : 9 ~ 19
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UCI(KEPA) : I410-ECN-0101-2016-470-000964980