지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.8
- 수록면
- 119 - 126 (8page)
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Objectives：The use of benzodiazepine and sleep deficiency both impair psychomotor function. Individuals with insufficient sleep often take benzodiazepine during the day for various reasons, such as anxiety. However, few studies have examined the extent to which the psychomotor effects of benzodiazepine interact with insufficient sleep. Therefore, this study examined the interaction of benzodiazepine and sleep deprivation on psychomotor function in healthy young males.
Methods：Four healthy males(age 23-26 years) participated in this study. Using a double-blind, placebo-controlled, crossover design, each subject was administered one of the following four conditions in a random order at 1-week intervals : 8 h in bed?placebo ; 8 h in bed?0.5 mg lorazepam ; 4 h in bed?placebo ; or 4 h in bed?0.5 mg lorazepam. Psychomotor functions were assessed at baseline and five times over 8.5 h after taking the study medications using the Critical Flicker Fusion Threshold, Choice Reaction Time, Compensatory Tracking Task, Digit Symbol Substitution Test, and Color-Word Stroop Tests.
Results：On the Color Stroop Test, there were significant differences among the conditions at 6.5(T4)(χ2=8.100, p= 0.044) and 8.5(T5)(χ2=8.100, p=0.044) h post-dose. In post hoc tests, 4 h in bed?0.5 mg lorazepam tended to cause more impairment than the other conditions.
Conclusion：There was some evidence that benzodiazepine-induced psychomotor impairment is potentiated by sleep deprivation. Future studies with larger sample sizes are required to validate this finding.
Methods：Four healthy males(age 23-26 years) participated in this study. Using a double-blind, placebo-controlled, crossover design, each subject was administered one of the following four conditions in a random order at 1-week intervals : 8 h in bed?placebo ; 8 h in bed?0.5 mg lorazepam ; 4 h in bed?placebo ; or 4 h in bed?0.5 mg lorazepam. Psychomotor functions were assessed at baseline and five times over 8.5 h after taking the study medications using the Critical Flicker Fusion Threshold, Choice Reaction Time, Compensatory Tracking Task, Digit Symbol Substitution Test, and Color-Word Stroop Tests.
Results：On the Color Stroop Test, there were significant differences among the conditions at 6.5(T4)(χ2=8.100, p= 0.044) and 8.5(T5)(χ2=8.100, p=0.044) h post-dose. In post hoc tests, 4 h in bed?0.5 mg lorazepam tended to cause more impairment than the other conditions.
Conclusion：There was some evidence that benzodiazepine-induced psychomotor impairment is potentiated by sleep deprivation. Future studies with larger sample sizes are required to validate this finding.
목차
서론
대상 및 방법
결과
고찰
참고문헌
참고문헌 (48)
참고문헌 신청
1. [단행본] - Sadock BJ / 2007 / Kaplan & Sadock’s synopsis of psychiatry: behavioral sciences/clinical psychiatry / Lippincott Williams &Wilkins : 1018 ~ 1023
2. [학술지(정기간행물)] - Ray WA / 1987 / Psychotropic drug use and the risk of hip fracture / N Engl J Med 316 : 363 ~ 369
3. [학술지(정기간행물)] - Sterke CS / 2008 / The influence of drug use on fall incidents among nursing home residents : a systematic review / Int Psychogeriatr 20 : 890 ~ 910
4. [학술지(정기간행물)] - Hartikainen S / 2007 / Medication as a risk factor for falls: critical systematic review / J Gerontol A Biol Sci Med Sci 62 : 1172 ~ 1181
5. [학술지(정기간행물)] - Barbone F / 1998 / Association of road-traffic accidents with BZD use / The Lancet 352 : 1331 ~ 1336
2. [학술지(정기간행물)] - Ray WA / 1987 / Psychotropic drug use and the risk of hip fracture / N Engl J Med 316 : 363 ~ 369
3. [학술지(정기간행물)] - Sterke CS / 2008 / The influence of drug use on fall incidents among nursing home residents : a systematic review / Int Psychogeriatr 20 : 890 ~ 910
4. [학술지(정기간행물)] - Hartikainen S / 2007 / Medication as a risk factor for falls: critical systematic review / J Gerontol A Biol Sci Med Sci 62 : 1172 ~ 1181
5. [학술지(정기간행물)] - Barbone F / 1998 / Association of road-traffic accidents with BZD use / The Lancet 352 : 1331 ~ 1336
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UCI(KEPA) : I410-ECN-0101-2016-513-001023715