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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.9
- 수록면
- 133 - 146 (14page)
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초록· 키워드
오류제보하기
Inflammasome is a cytosolic multiprotein complex to activate caspase-1 leading to the subsequent processing of inactive pro-interleukin-1-beta (Pro-IL-1β) into its active interleukin-1 beta (IL-1β) in response to pathogen- or dangerassociated molecular pattern. In recent years, a huge progress has been made to identify inflammasome component as a molecular platform to recruit and activate caspase-1. Nucleotide-binding oligomerization domain-like receptor (NLR) family proteins such as NLRP1, NLRP3 or interleukin-1β-converting enzyme (ICE)-protease activating factor (IPAF) have been first characterized to form inflammasome complex to induce caspase-1 activation. More recently, non-NLR type, pyrin-domain (PYD)-containing proteins such as pyrin or absent in melanoma2 (AIM2) were also proposed to form caspase-1-activating inflammasome machinery with apoptosis-associated speck-like protein containing a CARD (ASC), an essential adaptor molecule. Inflammasome pathways were shown to be crucial for protecting host organisms against diverse pathogen infections, but accumulating evidences also suggest that excessive activation of inflammasome/ caspase-1 might be related to the pathogenesis of inflammation-related diseases. Indeed, mutations in NLRP3 or pyrin are closely associated with autoinflammatory diseases such as familial Mediterranean fever (FMF) syndrome or Muckle-Wells syndrome (MWS), indicating that the regulation of caspase-1 activity by inflammasome is a central process in these hereditary inflammatory disorders. Here, recent advances on the molecular mechanism of caspase-1 activation by PYD-containing inflammasomes are summarized and discussed.
목차
Pattern-recognition receptors
Caspase-1: Inflammatory caspase
ASC: a key adaptor molecule for caspase-1activation and pyroptotic cell death
NLR subfamily
NLRP3 inflammasome
Pyrin inflammasome inautoinflammatory syndrome
AIM2 inflammasome: Molecular sensor forcytosolic double-stranded DNA
Concluding Remarks
REFERENCES
참고문헌 (104)
참고문헌 신청
1. [학술지(정기간행물)] - Takeuchi O / 2010 / Pattern recognition receptors and inflammation / Cell 140 : 805 ~ 820
2. [학술지(정기간행물)] - Kawai T / 2006 / TLR signaling / Cell Death Differ 13 : 816 ~ 825
3. [학술지(정기간행물)] - O'Neill LA / 2007 / The family of five: TIRdomain- containing adaptors in Toll-like receptor signalling / Nat Rev Immunol 7 : 353 ~ 364
4. [학술지(정기간행물)] - Trinchieri G / 2007 / Cooperation of Toll-like receptor signals in innate immune defence / Nat Rev Immunol 7 : 179 ~ 190
5. [학술지(정기간행물)] - Schroder K / 2010 / / Cell 140 : 821 ~ 832
2. [학술지(정기간행물)] - Kawai T / 2006 / TLR signaling / Cell Death Differ 13 : 816 ~ 825
3. [학술지(정기간행물)] - O'Neill LA / 2007 / The family of five: TIRdomain- containing adaptors in Toll-like receptor signalling / Nat Rev Immunol 7 : 353 ~ 364
4. [학술지(정기간행물)] - Trinchieri G / 2007 / Cooperation of Toll-like receptor signals in innate immune defence / Nat Rev Immunol 7 : 179 ~ 190
5. [학술지(정기간행물)] - Schroder K / 2010 / / Cell 140 : 821 ~ 832
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