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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.19 No.3
- 발행연도
- 2014.9
- 수록면
- 145 - 155 (11page)
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초록· 키워드
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Vascular dementia is characterized by white matter lesions involving the demyelination and activation of astrocytes and microglia. In a previous study, we showed that the supernatant of a laboratory-scale, hot water extract of ground whole wheat (TALE) attenuated white matter injury and astrocytic activation in a rat model of bilateral common carotid artery occlusion (BCCAO). In the present study, we made several modifications to the hot water extraction process to remove starch and enable large-scale production. We used wheat bran (WB), which contains less starch, instead of ground whole wheat. In addition, we removed starch granules with a decanter before hot water extraction. The final product, wheat bran extract (WBE), contained 2.42% arabinose, a surrogate marker of arabinoxylan, which is an active constituent of WBE. Supplementation of the rat model of BCCAO with WBE (400 mg/kg/day) for 33 days attenuated white matter injury, which was assessed by Luxol Fast Blue staining, in the corpus callosum (cc) and optic tract (opt) regions. Attenuation of white matter injury in the opt region was accompanied by improvement of the pupillary light reflex. Immunochemical staining revealed that supplementation with WBE reduced astrocytic activation in the cc and opt regions and reduced microglial activation in the opt region. These findings indicate that supplementation with WBE is effective at attenuating white matter injury accompanied by the inhibition of astrocytic and microglial activation. Therefore, extracts from WB, a cheap by-product of wheat milling, can be developed as a nutraceutical to prevent vascular dementia, a disease for which there is no approved pharmaceutical treatment.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (45)
참고문헌 신청
1. [학술지(정기간행물)] - Jellinger KA / 2013 / Pathology and pathogenesis of vascular cognitive impairment-a critical update / Front Aging Neurosci 5 : 17 ~
2. [학술지(정기간행물)] - Kalaria RN / 2008 / Alzheimer's disease and vascular dementia in developing countries: prevalence, management, and risk factors / Lancet Neurol 7 : 812 ~ 826
3. [학술지(정기간행물)] - Tomimoto H / 2011 / Subcortical vascular dementia / Neurosci Res 71 : 193 ~ 199
4. [학술지(정기간행물)] - Roman GC / 2002 / Sucortical ischaemic vascular dementia / Lancet Neurol 1 : 426 ~ 436
5. [학술지(정기간행물)] - Black S / 2009 / Understanding white matter disease: imaging-pathological correlations in vascular cognitive impairment / Stroke 40 : S48 ~ S52
2. [학술지(정기간행물)] - Kalaria RN / 2008 / Alzheimer's disease and vascular dementia in developing countries: prevalence, management, and risk factors / Lancet Neurol 7 : 812 ~ 826
3. [학술지(정기간행물)] - Tomimoto H / 2011 / Subcortical vascular dementia / Neurosci Res 71 : 193 ~ 199
4. [학술지(정기간행물)] - Roman GC / 2002 / Sucortical ischaemic vascular dementia / Lancet Neurol 1 : 426 ~ 436
5. [학술지(정기간행물)] - Black S / 2009 / Understanding white matter disease: imaging-pathological correlations in vascular cognitive impairment / Stroke 40 : S48 ~ S52
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