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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.6
- 수록면
- 131 - 138 (8page)
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초록· 키워드
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Radix Astragali, the root of Astragalus (A.) membranaceus, has been applied in a variety of diseases for a long time in Asian countries such as Korea and China. In addition, the aerial parts such as leaves and stems of A. membranaceus have received a great deal of attention. Recently, the polysaccharide fraction showing a potent immunomoduating activity was isolated from the aerial parts of A. membranaceus. Thus, the aerial parts of A. membranaceus would be worthy enough for a food material and a dietary supplement. However, they should be safe even though valuable. In our previous study, it was estimated that NOAEL for female rats are 5000 mg/kg/day of the crude polysaccharide fraction from A. membranaceusaboveground parts. As a series of safety evaluation, genotoxicity test for the crude polysaccharide fraction was carried out in this study. In conclusion, the three genotoxicity assays provided strong overall support that the crude polysaccharide fraction lacks mutagenic and/or clastogenic potential under the GLP-based test conditions. This indicates the aerial parts of A. membranaceus would be safe enough for a food material and a dietary supplement.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (18)
참고문헌 신청
Gui, S. Y. / 2006 / Effects and mechanisms of crude astragalosides fraction on liver fibrosis in rats / J. Ethnopharmacol 103:154~159
Sinclair, S. / 1998 / Chinese herbs: A clinical review of astragalus, ligusticum, and schizandra / Altern. Med. Rev 3:338~344
Zhang, X. / 2005 / Effects of single herbal drugs on adhesion and migration of melanocytes / J. Tradit. Chin. Med 25:219~221
Ma, X. Q. / 2002 / Chemical analysis of Radix Astragali (Huangqi) in China: A comparison with its adulterants and seasonal variations / J. Agric. Food Chem 50
McKenna, D. J. / 2002 / Astragalus / Int. J. Integr. Med 8:34~40
Sinclair, S. / 1998 / Chinese herbs: A clinical review of astragalus, ligusticum, and schizandra / Altern. Med. Rev 3:338~344
Zhang, X. / 2005 / Effects of single herbal drugs on adhesion and migration of melanocytes / J. Tradit. Chin. Med 25:219~221
Ma, X. Q. / 2002 / Chemical analysis of Radix Astragali (Huangqi) in China: A comparison with its adulterants and seasonal variations / J. Agric. Food Chem 50
McKenna, D. J. / 2002 / Astragalus / Int. J. Integr. Med 8:34~40
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