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논문 기본 정보

자료유형
학술저널
저자정보
Jung Hyu Shin (Korea Research Institute of Bioscience and Biotechnology) Chang Woo Lee (Korea Research Institute of Bioscience and Biotechnology) Soo Jin Oh (Korea Research Institute of Bioscience and Biotechnology) Jieun Yun (Korea Research Institute of Bioscience and Biotechnology) Moo Rim Kang (Korea Research Institute of Bioscience and Biotechnology) Sang-Bae Han (Chungbuk National University) Heungsik Park (Novarex) Jae Chul Jung (Novarex) Yoon Hoo Chung (Namhaegun Blackgarlic) Jong Soon Kang (Korea Research Institute of Bioscience and Biotechnology)
저널정보
한국독성학회 Toxicological Research Toxicological Research Vol.30 No.1
발행연도
2014.3
수록면
49 - 54 (6page)

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초록· 키워드

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In this study, we investigated the hepatoprotective effects of aged black garlic (ABG) in rodent models of liver injury. ABG inhibited carbon tetrachloride-induced elevation of aspartate transaminase (AST) and alanine transaminase (ALT), which are markers of hepatocellular damage, in SD rats. D-galactosamineinduced hepatocellular damage was also suppressed by ABG treatment. However, ABG does not affect the elevation of alkaline phosphatase (ALP), a marker of hepatobilliary damage, in rats treated with carbon tetrachloride or D-galactosamine. We also examined the effect of ABG on high-fat diet (HFD)-induced fatty liver and subsequent liver damage. ABG had no significant effect on body weight increase and plasma lipid profile in HFD-fed mice. However, HFD-induced increase in AST and ALT, but not ALP, was significantly suppressed by ABG treatment. These results demonstrate that ABG has hepatoprotective effects and suggest that ABG supplementation might be a good adjuvant therapy for the management of liver injury.

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INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES

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