지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.12
- 수록면
- 285 - 294 (10page)
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초록· 키워드
오류제보하기
Chungyangeum (CYE) is a newly designed herbal drug formula for the purpose of treating atopic dermatitis. The aim of the present study is to elucidate whether and how CYE modulates the allergy inflammation in vitro and in vivo. We investigate to ascertain the pharmacological effects of CYE on both compound 48/80 or histamine-induced scratching behaviors and 2, 4-dinitrochlrobenzene (DNCB)-induced atopic dermatitis in mice. Additionally, we attempted to determine the effects of CYE on lipopolysaccharide (LPS)-induced inflammatory responses in macrophages. The findings of this study demonstrated that CYE reduced compound 48/80 or histamine-induced scratching behaviors and DNCBinduced atopic dermatitis in mice. The CYE inhibited the production of inflammatory cytokines as well as the activation of NF-κB and caspase-1 in stimulated macrophages. Collectively, the findings of this study provide us with novel insights into the pharmacological actions of CYE as a potential molecule for use in the treatment of allergic inflammation diseases.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (22)
참고문헌 신청
1. [학술지(정기간행물)] - Allam JP / 2006 / The pathophysiology of atopic eczema / Clin Exp Dermatol 31 : 89 ~ 93
2. [학술지(정기간행물)] - Bauernfeind FG / 2009 / Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression / J Immunol 183 : 787 ~ 791
3. [학술지(정기간행물)] - Boero S / 2010 / Modulation by flunisolide of tumor necrosis factor-alpha-induced stimulation of airway epithelial cell activities related to eosinophil inflammation / J Asthma 47 : 381 ~ 387
4. [학술지(정기간행물)] - Brenninkmeijer EE / 2008 / Clinical differences between atopic and atopiform dermatitis / J Am Acad Dermatol 58 : 407 ~ 414
5. [학술지(정기간행물)] - Buske-Kirschbaum A / 2001 / Psychobiological aspects of atopic dermatitis: an overview / Psychother Psychosom 70 : 6 ~ 16
2. [학술지(정기간행물)] - Bauernfeind FG / 2009 / Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression / J Immunol 183 : 787 ~ 791
3. [학술지(정기간행물)] - Boero S / 2010 / Modulation by flunisolide of tumor necrosis factor-alpha-induced stimulation of airway epithelial cell activities related to eosinophil inflammation / J Asthma 47 : 381 ~ 387
4. [학술지(정기간행물)] - Brenninkmeijer EE / 2008 / Clinical differences between atopic and atopiform dermatitis / J Am Acad Dermatol 58 : 407 ~ 414
5. [학술지(정기간행물)] - Buske-Kirschbaum A / 2001 / Psychobiological aspects of atopic dermatitis: an overview / Psychother Psychosom 70 : 6 ~ 16
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