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자료유형
학술저널
저자정보
이지혜 (대구한의대학교) 조대희 (모세메디) 최영호 (모세메디) 정찬경 (모세메디) 최윤석 (모세메디) 차미경 (모세메디) 정지욱 (대구한의대학교)
저널정보
한의병리학회 동의생리병리학회지 동의생리병리학회지 제27권 제6호
발행연도
2013.12
수록면
789 - 794 (6page)
DOI
10.15188/kjopp.2013.12.27.6.789

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Hemorrhage is a devastating type of stroke, accounts for 15-20% of all strokes. This disease can cause cognitive dysfunction with a very high mortality rate. Cupping therapy of Traditional Korean medicine has frequently been used to relieve a variety of diseases or clinical conditions, although not in the memory loss after hemorrhage. This study was designed to evaluate the effects of cupping therapy on learning and memory with Y-maze test, as well as its effects on different molecular changes in hippocampus following the induction of hemorrhage in rats. Cupping, using vacuum cupping machine, was applied at target area for 5 min daily for 7 consecutive days, commencing 1 day after brain impairment. As a result, induction of hemorrhage enhanced memory deficit, suppressed brain-derived neurotrophin factor (BDNF) in the hippocampus. Cupping treatment effectively reversed collagenase-induced cognitive impairment in SD rats which was represented by improvement of spontaneous alterations in Y-maze test. In addition, BDNF expression was enhanced after cupping therapy. The present results suggest that the therapeutic effects of cupping treatment after hemorrhage is involved in expression of BDNF.

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