지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Jakyaktang(芍藥湯; JYT) exhibits potent anti-inflammatory activity in widely intestinal disease, but its mechanism was undisclosed. To elucidate the molecular mechanisms of JYT on pharmacological and biochemical actions in inflammation, we examined the effect of JYT on pro-inflammatory mediators in phorbol 12-myristate 13-acetate (PMA) plus A23187-induced mast cell and lipopolysaccharide (LPS)-stimulated macrophages. The investigation focused on whether JYT inhibited pro-inflammatory cytokines such as interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor-α (TNF-α) in PMA plus A23187- induced HMC-1 cells and inflammatory madiators such as nitric oxide (NO), TNF-α, IL-6, iNOS, COX-2 in LPS-stimulated RAW 264.7 cells. We found that JYT inhibited LPS-induced NO, TNF-α and IL-6 productions as well as the expressions of iNOS and COX-2. These results suggest that JYT has inhibitory effects on mast cell-mediated and macropage-mediated inflammation.
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참고문헌
참고문헌 (38)
참고문헌 신청
1. [단행본] - cuixun / 2002 / 方劑學 問題集 / 집문당 : 89 ~
2. [학술지(정기간행물)] - 서철훈 / 2006 / 濕熱痢로 변증한 궤양성 대장염 환자의 芍藥湯加味方 치험 2례 / 대한한방내과학회지 27 (4) : 984 ~ 990
3. [단행본] - Tizard, I.R / 1986 / Immunology, An introduction inflammation. 2nd ed / Saunders College Publishing : 423 ~ 441
4. [학술지(정기간행물)] - Willoughby, D.A / 1975 / Heberden Oration, 1974. Human arthritis applied to animal models. Towards a better therapy / Ann Rheum Dis 34 : 471 ~ 478
5. [학술지(정기간행물)] - Higuchi, M. / 1990 / Cytolytic mechanisms of activated macrophages. Tumor necrosis factor and L-argininedependent mechanisms act synergistically as the major cytolytic mechanisms of activated macrophages / J Immunol 144 : 1425 ~ 1431
2. [학술지(정기간행물)] - 서철훈 / 2006 / 濕熱痢로 변증한 궤양성 대장염 환자의 芍藥湯加味方 치험 2례 / 대한한방내과학회지 27 (4) : 984 ~ 990
3. [단행본] - Tizard, I.R / 1986 / Immunology, An introduction inflammation. 2nd ed / Saunders College Publishing : 423 ~ 441
4. [학술지(정기간행물)] - Willoughby, D.A / 1975 / Heberden Oration, 1974. Human arthritis applied to animal models. Towards a better therapy / Ann Rheum Dis 34 : 471 ~ 478
5. [학술지(정기간행물)] - Higuchi, M. / 1990 / Cytolytic mechanisms of activated macrophages. Tumor necrosis factor and L-argininedependent mechanisms act synergistically as the major cytolytic mechanisms of activated macrophages / J Immunol 144 : 1425 ~ 1431
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