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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Ketoconazole (KET) is an antifungal drug with a broad spectrum of activity that also induces reproductive toxicity in humans and animals. KET inhibits C17-20 lyase which blocks the conversion of 17 α-hydroxyprogesterone to androstenedione. The effect of Cuscutae semen(CS) extract against KET-induced testicular damage was evaluated in male rats. CS extract was administered orally (100 and 200 mg/kg) for 26 days. Three weeks after CS extract administration, KET was CS-administered intraperitoneally at a dose of 100 mg/kg once a day for 5 days. KET-induced reproductive toxicity was associated with clear reductions of the weights of testes and epididymides, sperm indices and serum testosterone levels. In addition, marked oxidative damage to testicular lipids and alterations of natural antioxidant enzymes were reported in association with KET toxicity. Most of the KET-induced effects were greatly decreased with the concomitant application of CS extract. This study suggests a protective role of Cuscutae semen extract that could be attributed to its antioxidant properties.
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참고문헌 (33)
참고문헌 신청
1. [학술지(정기간행물)] - 권강범 / 2004 / 加味馬錢五子丸 추출물이 雄性 白鼠의 성기능에 미치는 효과 / 동의생리병리학회지 18 (5) : 1410 ~ 1417
2. [학술지(정기간행물)] - Chandra, A. / 1998 / Impaired fecunfity in the United States; 1982-1995 / Fam. Plann. Perspect 30 : 34 ~ 42
3. [학술지(정기간행물)] - Mosher, W.D / 1982 / Reproductive inpairements in the United States; 1965-1982 / Demography 22 : 415 ~ 430
4. [학술지(정기간행물)] - Foresta, C. / 2001 / chromosome microdeletions and alterations of spermatogenesis / Endocr. Rev 22 : 226 ~ 239
5. [학술지(정기간행물)] - Pan, H.J / 2005 / Adjuvant effect of ethanol extract of Semen cuscutae on the immune responses to ovalbumin in mice / J. Ethnopharm 99 (1) : 99 ~ 103
2. [학술지(정기간행물)] - Chandra, A. / 1998 / Impaired fecunfity in the United States; 1982-1995 / Fam. Plann. Perspect 30 : 34 ~ 42
3. [학술지(정기간행물)] - Mosher, W.D / 1982 / Reproductive inpairements in the United States; 1965-1982 / Demography 22 : 415 ~ 430
4. [학술지(정기간행물)] - Foresta, C. / 2001 / chromosome microdeletions and alterations of spermatogenesis / Endocr. Rev 22 : 226 ~ 239
5. [학술지(정기간행물)] - Pan, H.J / 2005 / Adjuvant effect of ethanol extract of Semen cuscutae on the immune responses to ovalbumin in mice / J. Ethnopharm 99 (1) : 99 ~ 103
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