지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.4
- 수록면
- 165 - 175 (11page)
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초록· 키워드
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The fear that schistosomes will become resistant to praziquantel (PZQ) motivates the search for alternatives to treat schistosomiasis. The antimalarials quinine (QN) and halofantrine (HF) possess moderate antischistosomal properties. The major metabolic pathway of QN and HF is through cytochrome P450 (CYP) 3A4. Accordingly, this study investigates the effects of CYP3A4 inhibitor, ketoconazole (KTZ), on the antischistosomal potential of these quinolines against Schistosoma mansoni infection by evaluating parasitological, histopathological, and biochemical parameters. Mice were classified into 7 groups: uninfected untreated (I), infected untreated (II), infected treated orally with PZQ (1,000 mg/kg) (III), QN (400 mg/kg) (IV), KTZ (10 mg/kg)+QN as group IV (V), HF (400 mg/kg) (VI), and KTZ (as group V)+HF (as group VI) (VII). KTZ plus QN or HF produced more inhibition (P<0.05) in hepatic CYP450 (85.7% and 83.8%) and CYT b5 (75.5% and 73.5%) activities, respectively, than in groups treated with QN or HF alone. This was accompanied with more reduction in female (89.0% and 79.3%), total worms (81.4% and 70.3%), and eggs burden (hepatic; 83.8%, 66.0% and intestinal; 68%, 64.5%), respectively, and encountering the granulomatous reaction to parasite eggs trapped in the liver. QN and HF significantly (P<0.05) elevated malondialdehyde levels when used alone or with KTZ. Meanwhile, KTZ plus QN or HF restored serum levels of ALT, albumin, and reduced hepatic glutathione (KTZ+HF) to their control values. KTZ enhanced the therapeutic antischistosomal potential of QN and HF over each drug alone. Moreover, the effect of KTZ+QN was more evident than KTZ+HF.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (67)
참고문헌 신청
1. [학술지(정기간행물)] - King CH / 2008 / The unacknowledged impact of chronic schistosomiasis / Chronic Illn 4 : 65 ~ 79
2. [단행본] - Davis A / 2009 / Schistosomiasis, In Manson’s Tropical Diseases / Saunders : 1413 ~ 1456
3. [학술지(정기간행물)] - Utzinger J / 2009 / Schistosomiasis and neglected tropical diseases: towards integrated and sustainable control and a word of caution / Parasitology 136 : 1859 ~ 1874
4. [학술지(정기간행물)] - King CH / 2005 / Reassessment of the cost of chronic helmintic infection: a meta-analysis of disability-related outcomes in endemic schistosomiasis / Lancet 365 : 1561 ~ 1569
5. [학술지(정기간행물)] - Melman SD / 2009 / Reduced susceptibility to praziquantel among naturally occurring Kenyan isolates of Schistosoma mansoni / PLoS Negl Trop Dis 3 : e504 ~
2. [단행본] - Davis A / 2009 / Schistosomiasis, In Manson’s Tropical Diseases / Saunders : 1413 ~ 1456
3. [학술지(정기간행물)] - Utzinger J / 2009 / Schistosomiasis and neglected tropical diseases: towards integrated and sustainable control and a word of caution / Parasitology 136 : 1859 ~ 1874
4. [학술지(정기간행물)] - King CH / 2005 / Reassessment of the cost of chronic helmintic infection: a meta-analysis of disability-related outcomes in endemic schistosomiasis / Lancet 365 : 1561 ~ 1569
5. [학술지(정기간행물)] - Melman SD / 2009 / Reduced susceptibility to praziquantel among naturally occurring Kenyan isolates of Schistosoma mansoni / PLoS Negl Trop Dis 3 : e504 ~
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UCI(KEPA) : I410-ECN-0101-2014-510-002535453