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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.2
- 수록면
- 50 - 57 (8page)
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NF-κB is a transcriptional factor which is involved in many biological processes including immunity, inflammation, and cell survival. Many investigators studied on the mechanism involved in activation of NF-κB signalling pathway via ubiquitination and degradation of IκB regarding skin disease. Some specific molecules including Akt, MEK, p38 MAP Kinase, Stat3, et al. represent convergence points and key regulatory proteins in signaling pathways controlling cellular events such as growth and differentiation, energy homeostasis, and the response to stress and inflammation. Ultraviolet (UV) irradiation has many adverse effects on skin, including inflammation, alteration in the extracellular matrix, cellular senescence, apoptosis and skin cancer. Prunus mume, a naturally derived plant extract, has beneficial biological activities as blood fluidity improvement, anti-fatigue action, antioxidative and free radical scavenging activities, inhibiting the motility of Helicobacter pyolri. Previous reports on various beneficial function prompted us to investigate UVB-induced or other immunostimulated biological marker regarding P. mume extract. P. mume extract suppresses UVB-induced cyclooxygenase-2 (COX-2) expression in mouse skin epidermal JB6 P+ cells. The activation of activator protein-1 and nuclear factor-κB induced by UVB was dose-dependently inhibited by P. mume extract treatment. This results suggest that P. mume extracts might be used as a potential agents for protection of inflammation or UVB induced skin damage.
목차
Abstract
1. 서론
2. 연구방법
3. 연구결과 및 고찰
4. 결론
참고문헌
참고문헌 (36)
참고문헌 신청
1. [학술지(정기간행물)] - Beissert, S / 1996 / UV-induced cutaneous photobiology / Crit. Rev. Biochem. Mol. Biol 31 : 381 ~ 404
2. [학술지(정기간행물)] - Matsumuram Y / 2002 / Short-term and long-term cellular and molecular events following UV irradiation of skin: implications for molecular medicine / Expert Rev. Mol. Med 26 : 1 ~ 22
3. [학술지(정기간행물)] - Sen, R. / 1988 / Inducibility of kappa immunoglobulin enhancer-binding protein NF-kappa B by a posttranslational mechanism / Cell 47 : 921 ~ 928
4. [학술지(정기간행물)] - DiDonato, J. A. / 1997 / cytokine-responsive IkB kinase that activates the transcriptional factor NF-kB / Nature 388 : 548 ~ 554
5. [학술지(정기간행물)] - Lin, A / 2003 / NF-kB in cancer: a marked target / Semin. Cancer Biol 13 : 107 ~ 114
2. [학술지(정기간행물)] - Matsumuram Y / 2002 / Short-term and long-term cellular and molecular events following UV irradiation of skin: implications for molecular medicine / Expert Rev. Mol. Med 26 : 1 ~ 22
3. [학술지(정기간행물)] - Sen, R. / 1988 / Inducibility of kappa immunoglobulin enhancer-binding protein NF-kappa B by a posttranslational mechanism / Cell 47 : 921 ~ 928
4. [학술지(정기간행물)] - DiDonato, J. A. / 1997 / cytokine-responsive IkB kinase that activates the transcriptional factor NF-kB / Nature 388 : 548 ~ 554
5. [학술지(정기간행물)] - Lin, A / 2003 / NF-kB in cancer: a marked target / Semin. Cancer Biol 13 : 107 ~ 114
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UCI(KEPA) : I410-ECN-0101-2015-400-001242925