Purpose: This study was conducted to investigate how a program using video-audio media will affect the knowledge level and compliance of the sick role of patients admitted for coronary angiography. Method: A non-equivalent control group non-synchronized design was used. Subjects were selected from patients admitted to the internal ward of a hospital in B city for coronary angiography between July 1 and September 31, 2010. Twenty subjects were assigned to the control and experimental group, respectively. Video-audio media developed by the authors was used as the experimental tool. The effects of the program were analyzed using a knowledge assessment tool and questionnaire for compliance of the sick role. The SPSS/WIN 14.0 program was used for data analysis. Result: The first hypothesis that the “experimental group receiving the program using video-audio media will report a higher level of knowledge compared to the control group” was supported. The second hypothesis that the “experimental group that received the program using video-audio media will report a higher level of compliance of sick role” was supported. Conclusion: The program using video-audio media was effective in enhancing patients" knowledge about the disease and compliance of the sick role. Thus, it can be an effective nursing intervention for patients with coronary artery disease.