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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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It has been reported that Chungkukjang, one of Korean traditional fermented soybean products, may improve hypertension, diabetes, and hyperlipidemia. In this study, we sought to investigate the immunoenhancing effects of Chungkukjang in ovariectomized mice. For the first period, female SLC ddy mice were either sham-operated (Sham; n=27) or ovariectomized (OVX; n=27). As a basal diet, ovariectomized mice were fed low-calcium diet for faster induction of osteoporosis for six weeks, and those in the Sham group were fed AIN-76 diet. For the second period, half of the OVX group (n=9) and the Sham group (n=9) were fed a Chungkukjang-based diet (CKJ); whereas the other half (OVX; n=9/ Sham; n=9) were fed a casein-based diet (CSI) for 8 weeks. After a second period, we collected the blood via heart puncture and measured the splenocytes proliferation, T lymphocyte subsets by flowcytometry, and levels of serum cytokines (IL-2, IL-4, IL-6, IL-10, IFN-γ and TNF-α) by ELISA assay. The OVX+CKJ group showed higher splenocytes proliferation, higher ratio of CD4/CD8, and lower levels of IL-6 and TNF-α cytokines compared to the OVX+CSI group. The Sham+CKJ group showed cytokine productions, such as higher levels of IL-10 and IFN-γ, and lower levels of IL-6 and TNF-α compared to the Sham+CSI group. The result of this study suggests that Chungkukjang may lower the proinflammatory cytokine levels in both the OVX and Sham groups. In addition, Chungkukjang could make a balance of T cell subset proliferations and enhance the splenocyte proliferations in the OVX group.
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REFERENCES
참고문헌 (54)
참고문헌 신청
1. [학술지(정기간행물)] - Lee BK. / 1997 / Immunomodulators extracted from Korean-style fermented soybean paste and their function. 1. Isolation of B cell mitogen from Korean-style fermented soybean paste / Korean J Immunol 19 : 559 ~ 570
2. [학술지(정기간행물)] - Adlercreutz H. / 1997 / Phyto-oestrogens and Western diseases / Ann Med 29 : 95 ~ 120
3. [학술지(정기간행물)] - Ko HS. / 1999 / The effect of quality improvement by Chungkuk-jang's processing methods / Korean J Food & Nutr 12 : 1 ~ 6
4. [학술지(정기간행물)] - 연규춘 / 2002 / Bacillus natto와 B. licheniformis의 혼합 Starter로 제조된 청국장의 품질특성 / 한국식품영양과학회지 31 (2) : 204 ~ 210
5. [학술지(정기간행물)] - Kim J. / 1998 / Physicochemical properties of traditional Chonggugjang produced in different regions / Agric Chem Biotechnol 41 : 377 ~ 383
2. [학술지(정기간행물)] - Adlercreutz H. / 1997 / Phyto-oestrogens and Western diseases / Ann Med 29 : 95 ~ 120
3. [학술지(정기간행물)] - Ko HS. / 1999 / The effect of quality improvement by Chungkuk-jang's processing methods / Korean J Food & Nutr 12 : 1 ~ 6
4. [학술지(정기간행물)] - 연규춘 / 2002 / Bacillus natto와 B. licheniformis의 혼합 Starter로 제조된 청국장의 품질특성 / 한국식품영양과학회지 31 (2) : 204 ~ 210
5. [학술지(정기간행물)] - Kim J. / 1998 / Physicochemical properties of traditional Chonggugjang produced in different regions / Agric Chem Biotechnol 41 : 377 ~ 383
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