지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Objectives: Previous reports have shown that Bogijetong-Tang (BJT) is effective in peripheral neuropathy induced by taxol and crush injury. In this study, we researched the effects of BJT on diabetic neuropathy induced by STZ in the mouse.
Methods: We performed both in vitro and in vivo experiments to verify the effects of BJT on diabetic neuropathy induced by STZ in mice. Changes in axonal recovery were observed with immunofluorescence staining using NF-200, Hoechst33258, S100β, caspase 3 and anti-cdc2. Proliferation and degeneration of Schwann cells were investigated by immunofluorescence staining and western blot analyses.
Results: BJT showed considerable effects on neurite outgrowth and axonal regeneration in diabetic neuropathy. BJT contributed to the creation of NF-200, GAP-43, Cdc2, phospho-vimentin, β1, active β1, β3 integrin, phospho-Erk1/2 protein.
Conclusions: Through this study, we found that BJT is effective for enhanced axonal regeneration via dynamic regulation of regeneration-associated proteins. Therefore, BJT had a pharmaceutical property enhancing recovery of peripheral nerves induced by diabetic neuropathy and could be a candidate for drug development after more research.
Methods: We performed both in vitro and in vivo experiments to verify the effects of BJT on diabetic neuropathy induced by STZ in mice. Changes in axonal recovery were observed with immunofluorescence staining using NF-200, Hoechst33258, S100β, caspase 3 and anti-cdc2. Proliferation and degeneration of Schwann cells were investigated by immunofluorescence staining and western blot analyses.
Results: BJT showed considerable effects on neurite outgrowth and axonal regeneration in diabetic neuropathy. BJT contributed to the creation of NF-200, GAP-43, Cdc2, phospho-vimentin, β1, active β1, β3 integrin, phospho-Erk1/2 protein.
Conclusions: Through this study, we found that BJT is effective for enhanced axonal regeneration via dynamic regulation of regeneration-associated proteins. Therefore, BJT had a pharmaceutical property enhancing recovery of peripheral nerves induced by diabetic neuropathy and could be a candidate for drug development after more research.
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참고문헌 (33)
참고문헌 신청
1. [단행본] - The Whole Country College Korean Medicine,Department of Singye Internal Medicine / 2011 / SingyeInternal Medicine / Koonja publishing co : 310 ~
2. [학술지(정기간행물)] - Shaw JE / 1999 / The epidemiology of diabeticneuropathy / Diabetes 7 : 245 ~ 252
3. [학술지(정기간행물)] - Kathleen M / 2003 / Botanicals and Dietary Supplements in DiabeticPeripheral Neuropathy / J Am Board Fam Pract 16 (1) : 47 ~ 57
4. [학술지(정기간행물)] - Kinoshita JH / 1988 / The involvement of aldosereductase in diabetic complications / DiabetesMetab 4 : 323 ~ 337
5. [학술지(정기간행물)] - Kaul CL / 2001 / The role of aldose reductaseinhibitions in diabetic complications: recent trends / Methods Find Exp Clin Phamacol 23 : 465 ~ 475
2. [학술지(정기간행물)] - Shaw JE / 1999 / The epidemiology of diabeticneuropathy / Diabetes 7 : 245 ~ 252
3. [학술지(정기간행물)] - Kathleen M / 2003 / Botanicals and Dietary Supplements in DiabeticPeripheral Neuropathy / J Am Board Fam Pract 16 (1) : 47 ~ 57
4. [학술지(정기간행물)] - Kinoshita JH / 1988 / The involvement of aldosereductase in diabetic complications / DiabetesMetab 4 : 323 ~ 337
5. [학술지(정기간행물)] - Kaul CL / 2001 / The role of aldose reductaseinhibitions in diabetic complications: recent trends / Methods Find Exp Clin Phamacol 23 : 465 ~ 475
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