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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.10
- 수록면
- 289 - 294 (6page)
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Resveratrol, natural polyphenol in grapes and red wine, is known to have the anti-proliferatory and anti-angiogenic effects in various cancer cells. In this study, we have investigated the effects of resveratrol in HT-29 colon cancer cells. Treatment of resveratrol in different concentrations and time inhibited proliferation of HT-29 colon cancer cells. We explored the effects of resveratrol on HT-29 colon cancer cell motility using a wound healing assay. In the absence of the resveratrol, the HT-29 cells are migrated along the edges of the wound and showed a large-scale migration, whereas dose- and time-dependent inhibition of cell flattening and spreading was observed in the presence of resveratrol. Resveratrol inhibited MMP-9 in a dose- and time-dependent on HT-29 colon cancer cells by Western blotting. In addition, resveratrol increased AMPK activity and decreased COX-2, VASP and VEGF expression. Treatment of compound C inhibited AMPK activity, however, the expression of VASP and COX-2 increased thus, COX-2 and VASP are modulated by AMPK. However treatment of celecoxib could not control AMPK activity but decreased VEGF expression. We suggest that resveratrol inhibits cell proliferation and migration through activation of AMPK and decreased COX-2, VASP and VEGF expression in HT-29 colon cancer cells.
목차
Abstract
1. 서론
2. 재료 및 방법
3. 결과 및 고찰
4. 결론
References
참고문헌 (19)
참고문헌 신청
1. [학술지(정기간행물)] - Jemal, A / 2010 / Cancer statistics / CA Cancer. J. Clin 30 : 277 ~ 300
2. [학술지(정기간행물)] - Hieken, T. J / 2001 / Predicting the biologic behavior of ductal carcinoma in situ: an analysis of molecular markers / Surgery 130 : 593 ~ 600
3. [학술지(정기간행물)] - Uchiyama, T / 2010 / Resveratrol inhibits angiogenic response of cultured endothelial F-2 cells to vascular endothelial growth factor, but not to basic fibroblast growth factor / Biol. Pharm. Bull 33 : 1095 ~ 1100
4. [학술지(정기간행물)] - Tseng, S. H / 2004 / Resveratrol suppresses the angiogenesis and tumor growth of gliomas in rats / Clin. Cancer Res 10 : 2190 ~ 2202
5. [학술지(정기간행물)] - Belguendouz, L / 1997 / Resveratrol inhibits metal ion-dependent and independent peroxidation of porcine low-density lipoproteins / Biochem Pharmacol 53 : 1347 ~ 1355
2. [학술지(정기간행물)] - Hieken, T. J / 2001 / Predicting the biologic behavior of ductal carcinoma in situ: an analysis of molecular markers / Surgery 130 : 593 ~ 600
3. [학술지(정기간행물)] - Uchiyama, T / 2010 / Resveratrol inhibits angiogenic response of cultured endothelial F-2 cells to vascular endothelial growth factor, but not to basic fibroblast growth factor / Biol. Pharm. Bull 33 : 1095 ~ 1100
4. [학술지(정기간행물)] - Tseng, S. H / 2004 / Resveratrol suppresses the angiogenesis and tumor growth of gliomas in rats / Clin. Cancer Res 10 : 2190 ~ 2202
5. [학술지(정기간행물)] - Belguendouz, L / 1997 / Resveratrol inhibits metal ion-dependent and independent peroxidation of porcine low-density lipoproteins / Biochem Pharmacol 53 : 1347 ~ 1355
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UCI(KEPA) : I410-ECN-0101-2014-400-002407720