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논문 기본 정보

자료유형
학술저널
저자정보
Jin Hee Maeng (Utah-Inha DDS and Advanced Therapeutics Research Center) Eunhye Lee (Utah-Inha DDS and Advanced Therapeutics Research Center) Don Haeng Lee (Utah-Inha DDS and Advanced Therapeutics Research Center) Su-Geun Yang (Inha University)
저널정보
한국실험동물학회 Laboratory Animal Research Laboratory Animal Research Vol.29 No.2
발행연도
2013.6
수록면
96 - 102 (7page)

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초록· 키워드

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In this study, we examined rabbit gastric ulcer models that can serve as more clinically relevant models. Two types of ulcer model were studied: acetic acid-induced ulcers (AAU) and mucosal resection-induced ulcers (MRU). For AAU, rabbit gastric mucosa was exposed by median laparotomy and treated with bottled acetic acid. MRU was examined as a model for endoscopic mucosal resection (EMR). Normal saline was injected into the submucosal layer and the swollen mucosa was resected with scissors. Endoscopic mucosal resection (EMR) is frequently performed for treatment of early gastric cancers. This procedure inevitably leads to ulcers and bleeding. Bleeding control is the major concern in endoscopic mucosectomy, and some endoscopic hemostatic agents are currently under clinical and preclinical studies. MRU was developed as a model for these induced ulcers and the evaluation of the healing process. The clinical relevancy of those models was compared with that of rat models. Progressive healing was observed for 7 days based on histology. Rabbit models demonstrate round, deep ulcers with clear margins and well-defined healing stages that were difficult to define in rat models.

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UCI(KEPA) : I410-ECN-0101-2014-500-003193960