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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.6
- 수록면
- 84 - 95 (12page)
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The aim of this study was to investigate the effects of Red L. platyphylla (RLP) on calcium and glucose levels during insulin secretion. To achieve this, alteration of insulin and calcium concentrations was measured in rat insulinoma-1 (INS-1) cells and animal models in response to RLP treatment. In INS-1 cells, maximum secretion of insulin was detected upon treatment with 200 μg/mL of RLP for 20 min. Nifedipine, an L-type calcium channel blocker, effectively inhibited insulin secretion from INS-1 cells. Regarding calcium levels, the maximum concentration of intracellular calcium in INS-1 cells was obtained by treatment with 100 μg/mL of RLP, whereas this level was reduced under conditions of 200 μg/mL of RLP. Further, RLP-treated INS-1 cells showed a higher level of intracellular calcium than that of L. platyphylla (LP), Korea White Ginseng (KWG), or Korea Red Ginseng (KRG)-treated cells. This RLP-induced increase in intracellular calcium was abrogated but not completely abolished upon treatment with 40 μM nifedipine in a dose-dependent manner. Furthermore, the insulin level was dramatically elevated upon cotreatment with high concentrations of glucose and RLP, whereas it was maintained at a low level in response to glucose and RLP co-treatment at low concentrations. In an animal experiment, the serum concentration of calcium increased or decreased upon RLP treatment according to glucose level compared to vehicle treatment. Therefore, these results suggest that insulin secretion induced by RLP treatment may be tightly correlated with calcium regulation, which suggests RLP is an excellent candidate for diabetes treatment.
목차
Materials and Methods
Results
Discussion
References
참고문헌 (21)
참고문헌 신청
1. [학술지(정기간행물)] - 허만규 / 2007 / 한국내 맥문동의 유전적 다양성과 집단 구조 / 생명과학회지 17 (3) : 328 ~ 333
2. [학술지(정기간행물)] - Lee YC / 2005 / Liriopistuber inhibit OVAinduced airway inflammation and bronchial hyperresponsiveness in murine model of asthma / J Ethnopharmacol 101 (1-3) : 144 ~ 152
3. [학술지(정기간행물)] - Choi SB / 2004 / The insulin sensitizing effect of homoisoflavone-enriched fraction in Liriope platyphylla Wang et Tang via PI3-kinase pathway / Life Sci 75 (22) : 2653 ~ 2664
4. [학술지(정기간행물)] - Hur J / 2004 / Induction of nerve growth factor by butanol fraction of Liriope platyphylla in C6 and primary astrocyte cells / Biol Pharm Bull 27 (8) : 1257 ~ 1260
5. [학술지(정기간행물)] - Jeong S / 2008 / The Korean traditional medicine Gyeongshingangjeehwan inhibits obesity through the regulation of leptin and PPARalpha action in OLETF rats / J Ethnopharmacol 119 (2) : 245 ~ 251
2. [학술지(정기간행물)] - Lee YC / 2005 / Liriopistuber inhibit OVAinduced airway inflammation and bronchial hyperresponsiveness in murine model of asthma / J Ethnopharmacol 101 (1-3) : 144 ~ 152
3. [학술지(정기간행물)] - Choi SB / 2004 / The insulin sensitizing effect of homoisoflavone-enriched fraction in Liriope platyphylla Wang et Tang via PI3-kinase pathway / Life Sci 75 (22) : 2653 ~ 2664
4. [학술지(정기간행물)] - Hur J / 2004 / Induction of nerve growth factor by butanol fraction of Liriope platyphylla in C6 and primary astrocyte cells / Biol Pharm Bull 27 (8) : 1257 ~ 1260
5. [학술지(정기간행물)] - Jeong S / 2008 / The Korean traditional medicine Gyeongshingangjeehwan inhibits obesity through the regulation of leptin and PPARalpha action in OLETF rats / J Ethnopharmacol 119 (2) : 245 ~ 251
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