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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.6
- 수록면
- 70 - 76 (7page)
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It has been generally accepted that calcium intake prevents bone loss, and frequent fracture resulted from osteoporosis. However, it is still elusive as to how effective sole calcium intake is in preventing or attenuating the severity of osteoporosis. Here, we demonstrate the effects of eggshell-casein phosphopeptide (ES-CPP), and compared these effects those of calcium supplement, for restoring ovariectomy-mediated bone loss. CPP, synthesized from the hydrolysis of casein (0.5%) using trypsin, was added to the grinded ES and was then administered to the ovariectomized (OVX) rat at 100 mg/kg for 4 weeks. Urine and feces from each group were collected each day, and were used to calculate the apparent calcium absorption rate in a day. After 4 weeks incubation, blood and femoral bones were isolated for the analysis of parameters representing osteoporosis. The apparent calcium absorption rate was significantly increased in the ES-CPP treated groups, in comparison to both the OVX and the commercial calcium supplement (CCS) treated group. Notably, treatment with ES-CPP markedly enhanced the calcium content in femoral bone and the relative weight of femoral bone to body weight, though calcium content in serum was barely changed by treatment with ES-CPP. Parameters of osteoporosis, such as osteocalcin in serum and bone mineral density, were rescued by treatment with ES-CPP, compared to treatment with commercial calcium supplement. This finding strongly suggests the possible use of ES-CPP in preventing or attenuating the severity of postmenopausal osteoporosis.
목차
Materials and Methods
Results
Discussion
References
참고문헌 (32)
참고문헌 신청
1. [학술지(정기간행물)] - Blair HC / 2011 / Calcium and bone disease / Biofactors 37 (3) : 159 ~ 167
2. [학술지(정기간행물)] - Belchetz PE / 1994 / Hormonal treatment of postmenopausal women / N Engl J Med 330 (15) : 1062 ~ 1071
3. [학술지(정기간행물)] - Mezquita Raya P / 2002 / Prevalence of vitamin D deficiency in populations at risk for osteoporosis: impact on bone integrity / Med Clin (Barc) 119 (3) : 85 ~ 89
4. [학술지(정기간행물)] - Nelson ER / 2013 / The molecular mechanisms underlying the pharmacological actions of estrogens, SERMs and oxysterols: implications for the treatment and prevention of osteoporosis / Bone 53 (1) : 42 ~ 50
5. [학술지(정기간행물)] - Rossouw JE / 2002 / Writing Group for the Women’s Health Initiative Investigators. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women’s Health Initiative randomized controlled trial / JAMA 288 (3) : 321 ~ 333
2. [학술지(정기간행물)] - Belchetz PE / 1994 / Hormonal treatment of postmenopausal women / N Engl J Med 330 (15) : 1062 ~ 1071
3. [학술지(정기간행물)] - Mezquita Raya P / 2002 / Prevalence of vitamin D deficiency in populations at risk for osteoporosis: impact on bone integrity / Med Clin (Barc) 119 (3) : 85 ~ 89
4. [학술지(정기간행물)] - Nelson ER / 2013 / The molecular mechanisms underlying the pharmacological actions of estrogens, SERMs and oxysterols: implications for the treatment and prevention of osteoporosis / Bone 53 (1) : 42 ~ 50
5. [학술지(정기간행물)] - Rossouw JE / 2002 / Writing Group for the Women’s Health Initiative Investigators. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women’s Health Initiative randomized controlled trial / JAMA 288 (3) : 321 ~ 333
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UCI(KEPA) : I410-ECN-0101-2014-500-003193935