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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.6
- 수록면
- 168 - 172 (5page)
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Toll-like receptors (TLRs) play an important role for host defense against invading pathogens. TLR4 has been identified as the receptor for lipopolysaccharide (LPS), which is a cell wall component of gram-negative bacteria. The activation of TLR4 signaling by LPS leads to the activation of NF-κB and the expression of pro-inflammatory gene products such as cytokines, inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2). To evaluate the therapeutic potential of (E)-1-(2-(2-nitrovinyl)phenyl)pyrrolidine (NVPP), previously synthesized in our laboratory, NF-κB activation and iNOS and COX-2 expression induced by LPS were examined. NVPP inhibited the activation of NF-κB induced by LPS. NVPP also suppressed the iNOS expression induced by LPS but it did not suppress COX-2 expression induced by LPS. These results suggest that NVPP has the specific mechanism for anti-inflammatory responses.
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참고문헌 (16)
참고문헌 신청
Akira S / 2004 / Toll-like receptor signalling / Nat Rev Immunol 4:499~511
Bjorkbacka H / 2004 / The induction of macrophage gene expression by LPS predom-inantly utilizes Myd88-independent signaling cascades / Physiol Genomics 19:319~330
Ferrero-Miliani L / 2007 / Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1beta generation / Clin Exp Immunol 147:227~235
Gao JJ / 1998 / Autocrine/paracrine IFN-alphabeta mediates the lipopolysaccharide-induced activation of transcription factor Stat1alpha in mouse macrophages: pivotal role of Stat1alpha in induction of the inducible nitric oxide synthase gene / J Immunol 161:4803~4810
Green SJ / 1990 / Activated macrophages destroy intracellular Leishmania major amastigotes by an L-arginine-dependent killing mechanism / J Immunol 144:278~283
Bjorkbacka H / 2004 / The induction of macrophage gene expression by LPS predom-inantly utilizes Myd88-independent signaling cascades / Physiol Genomics 19:319~330
Ferrero-Miliani L / 2007 / Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1beta generation / Clin Exp Immunol 147:227~235
Gao JJ / 1998 / Autocrine/paracrine IFN-alphabeta mediates the lipopolysaccharide-induced activation of transcription factor Stat1alpha in mouse macrophages: pivotal role of Stat1alpha in induction of the inducible nitric oxide synthase gene / J Immunol 161:4803~4810
Green SJ / 1990 / Activated macrophages destroy intracellular Leishmania major amastigotes by an L-arginine-dependent killing mechanism / J Immunol 144:278~283
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UCI(KEPA) : I410-ECN-0101-2014-500-003263001