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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Journal of the Korean Surgical Society Vol.84 No.6
- 발행연도
- 2013.6
- 수록면
- 338 - 345 (8page)
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초록· 키워드
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Purpose: The optimal time between neoadjuvant chemoradiotherapy (CRT) and surgery for rectal cancer has been debated. This study evaluated the influence of this interval on oncological outcomes. Methods: We compared postoperative complications, pathological downstaging, disease recurrence, and survival in patients with locally advanced rectal cancer who underwent surgical resection ＜8 weeks (group A, n = 105) to those who had surgery ≥8 weeks (group B, n = 48) after neoadjuvant CRT. Results: Of 153 patients, 117 (76.5%) were male and 36 (23.5%) were female. Mean age was 57.8 years (range, 28 to 79 years). There was no difference in the rate of sphincter preserving surgery between the two groups (group A, 82.7% vs. group B, 77.6%; P = 0.509). The longer interval group had decreased postoperative complications, although statistical significance was not reached (group A, 28.8% vs. group B, 14.3%; P = 0.068). A total of 111 (group A, 75 [71.4%] and group B, 36 [75%]) patients were downstaged and 26 (group A, 17 [16.2%] and group B, 9 [18%]) achieved pathological complete response (pCR). There was no significant difference in the pCR rate (P = 0.817). The longer interval group experienced significant improvement in the nodal (N) downstaging rate (group A, 46.7% vs. group B, 66.7%; P = 0.024). The local recurrence (P = 0.279), distant recurrence (P = 0.427), disease-free survival (P = 0.967), and overall survival (P = 0.825) rates were not significantly different. Conclusion: It is worth delaying surgical resection for 8 weeks or more after completion of CRT as it is safe and is associated with higher nodal downstaging rates.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (29)
참고문헌 신청
1. [학술지(정기간행물)] - de Campos-Lobato LF / 2011 / Neoadjuvant therapy for rectal cancer: the impact of longer interval between chemoradiation and surgery / J Gastrointest Surg 15 : 444 ~ 450
2. [학술지(정기간행물)] - Lim SB / 2008 / Optimal surgery time after preoperative chemoradiotherapy for locally advanced rectal cancers / Ann Surg 248 : 243 ~ 251
3. [학술지(정기간행물)] - Pahlman L. / 2009 / Optimal timing of surgery after preoperative chemoradiotherapy for rectal cancer / Nat Clin Pract Oncol 6 : 128 ~ 129
4. [학술지(정기간행물)] - Habr-Gama A / 2008 / Gama-Rodrigues J, et al. Interval between surgery and neoadjuvant chemoradiation therapy for distal rectal cancer: does delayed surgery have an impact on outcome? / Int J Radiat Oncol Biol Phys 71 : 1181 ~ 1188
5. [학술지(정기간행물)] - Colorectal Cancer Collaborative Group / 2001 / Adjuvant radiotherapy for rectal cancer: a systematic overview of 8,507 patients from 22 randomised trials / Lancet 358 : 1291 ~ 1304
2. [학술지(정기간행물)] - Lim SB / 2008 / Optimal surgery time after preoperative chemoradiotherapy for locally advanced rectal cancers / Ann Surg 248 : 243 ~ 251
3. [학술지(정기간행물)] - Pahlman L. / 2009 / Optimal timing of surgery after preoperative chemoradiotherapy for rectal cancer / Nat Clin Pract Oncol 6 : 128 ~ 129
4. [학술지(정기간행물)] - Habr-Gama A / 2008 / Gama-Rodrigues J, et al. Interval between surgery and neoadjuvant chemoradiation therapy for distal rectal cancer: does delayed surgery have an impact on outcome? / Int J Radiat Oncol Biol Phys 71 : 1181 ~ 1188
5. [학술지(정기간행물)] - Colorectal Cancer Collaborative Group / 2001 / Adjuvant radiotherapy for rectal cancer: a systematic overview of 8,507 patients from 22 randomised trials / Lancet 358 : 1291 ~ 1304
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UCI(KEPA) : I410-ECN-0101-2014-510-002571366