In this paper, a highly sensitive and simple electrochemical sensing platform which consists of carbon interdigitated array (IDA) nanoelectrodes integrated in a PDMS microchannel is introduced. In previous studies, the prospect of electrochemical sensors using carbon IDA nanoelectrodes capable of amplifying current signal by 29 times was demonstrated. This electrochemical signal amplification is based on redox cycling of redox species between the fingers of the IDA nanoelectrodes each of that experiences distinct redox reactions, that is reduction or oxidation depending on electrode potential. The redox cycling based signal amplification can be further enhanced by integrating a microchannel on top of the IDA nanoelectrodes. This is because the redox cycling effect is maintained steady while non-reversible species depletes faster as the microchannel size reduces. We present highly sensitive electrochemical sensors which have more than 2 order electrochemical signal amplification (>100) using only conventional soft lithography and carbon-MEMS process.