지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.2
- 수록면
- 963 - 972 (10page)
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초록· 키워드
오류제보하기
Exercise training improves motor function after clinical and experimental peripheral nervous lesion. However, it is not clear if clinical improvements are due to neuronal alterations within the affected axonal region or a result from a more general effect of exercise on affect and motivation.
In previous study, we found that treadmill exercise up regulate the neurotrophic factors in the mouse regeneration model. But still we don"t know about the detailed signaling in the median nerve and interactions between them and exercise. The purpose of this study was to determined the effects of treadmill exercise on nerve regeneration in median nerve cut and sutured peripheral nerve regeneration mouse model.
The results of this study were summarized as follows:
(1) Treadmill exercise group have more neurons in dorsal root ganglion(DRG).
(2) Treadmill exercise group"s p-ERKl/2 expression levels is more higher than sedentary group in median nerve. This means exercise inhibits apoptosis in the median nerve and induce the cell survival.
(3) Treadmill exercise increase GDNF expression levels in the median nerve proximal nerve stump rather than sedentary group.
This result(higher expression of p-ERKl/2, increased GDNF) means treadmill exercise profitable for prevent the nerve degeneration and induce the neuronal regeneration in the median nerve. The results of this study suggest that treadmill exercise inhibit the nerve regeneration in the injuried median nerve distal area and proximal nerve stump, and this effects were may offer a potential therapeutic adjunct to current nerve regeneration therapies in the future.
In previous study, we found that treadmill exercise up regulate the neurotrophic factors in the mouse regeneration model. But still we don"t know about the detailed signaling in the median nerve and interactions between them and exercise. The purpose of this study was to determined the effects of treadmill exercise on nerve regeneration in median nerve cut and sutured peripheral nerve regeneration mouse model.
The results of this study were summarized as follows:
(1) Treadmill exercise group have more neurons in dorsal root ganglion(DRG).
(2) Treadmill exercise group"s p-ERKl/2 expression levels is more higher than sedentary group in median nerve. This means exercise inhibits apoptosis in the median nerve and induce the cell survival.
(3) Treadmill exercise increase GDNF expression levels in the median nerve proximal nerve stump rather than sedentary group.
This result(higher expression of p-ERKl/2, increased GDNF) means treadmill exercise profitable for prevent the nerve degeneration and induce the neuronal regeneration in the median nerve. The results of this study suggest that treadmill exercise inhibit the nerve regeneration in the injuried median nerve distal area and proximal nerve stump, and this effects were may offer a potential therapeutic adjunct to current nerve regeneration therapies in the future.
목차
Abstract
I. 서론
II. 연구방법
III. 결과 및 논의
IV. 결론
참고문헌
참고문헌 (24)
참고문헌 신청
1. [학술지(정기간행물)] - Alvarez, F. J. / 2010 / Permanent reorganization of Ia afferent synapses on motoneurons after peripheral nerve injuries / Ann N Y Acad Sci 1198 : 231 ~ 241
2. [학술지(정기간행물)] - Bassel, M. / 2012 / Physical and occupational therapy referral and use among systemic sclerosis patients with impaired hand function: results from a Canadian national survey / Clin Exp Rheumatol 30 (4) : 574 ~ 577
3. [학술지(정기간행물)] - Bassel, M. / 2012 / Physical and occupational therapy referral and use among systemic sclerosis patients with impaired hand function: results from a Canadian national survey / Clin Exp Rheumatol 30 (4) : 574 ~ 577
4. [학술지(정기간행물)] - Brushart, T. M. / 1998 / Contributions of pathway and neuron to preferential motor reinnervation / J Neurosci 18 (21) : 8674 ~ 8681
5. [학술지(정기간행물)] - Brushart, T. M. / 1998 / Contributions of pathway and neuron to preferential motor reinnervation / J Neurosci 18 (21) : 8674 ~ 8681
2. [학술지(정기간행물)] - Bassel, M. / 2012 / Physical and occupational therapy referral and use among systemic sclerosis patients with impaired hand function: results from a Canadian national survey / Clin Exp Rheumatol 30 (4) : 574 ~ 577
3. [학술지(정기간행물)] - Bassel, M. / 2012 / Physical and occupational therapy referral and use among systemic sclerosis patients with impaired hand function: results from a Canadian national survey / Clin Exp Rheumatol 30 (4) : 574 ~ 577
4. [학술지(정기간행물)] - Brushart, T. M. / 1998 / Contributions of pathway and neuron to preferential motor reinnervation / J Neurosci 18 (21) : 8674 ~ 8681
5. [학술지(정기간행물)] - Brushart, T. M. / 1998 / Contributions of pathway and neuron to preferential motor reinnervation / J Neurosci 18 (21) : 8674 ~ 8681
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UCI(KEPA) : I410-ECN-0101-2014-692-000196315