지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objectives : It has been known that immune reaction plays an important role in the pathogenesis of otitis media (OM). We investigated the change of middle ear mucosal inflammation induced by lipopolysaccharide (LPS) following administration of Taglisodog-eum (TSE) in experimental animals.
Materials and Methods : Otitis media was induced by injecting 1 mg/kg of Pseudomonas aeruginosa LPS transtympanically in 60 rats. These rats were divided into two groups, the LPS group (n=30, remained naive after OM elicitation) and the TSE group (n=30, treated with TSE after OM elicitation) and 6 additional rats were kept as a normal control group (n=6, remained naive until tissue collection). The rats were killed at the 1st, 3rd, and 7th days after challenge. The temporal bones in each group were harvested and examined histopathologically by hematoxyline-eosin stain. Middle ear mucosa were taken at the 1st, 3rd, and 7th days after challenge. The levels of spicing variants of TNF-α transcription were evaluated by Realtime-PCR.
Results : TSE suppressed LPS-induced TNF-α mRNA expression and thickness of the submucosal layer and infiltration of inflammatory cells in rat middle ear epithelium.
Conclusion : The results suggest that TSE may be effective in decreasing inflammation with particular application to mucosal metaplasia in OM.
Materials and Methods : Otitis media was induced by injecting 1 mg/kg of Pseudomonas aeruginosa LPS transtympanically in 60 rats. These rats were divided into two groups, the LPS group (n=30, remained naive after OM elicitation) and the TSE group (n=30, treated with TSE after OM elicitation) and 6 additional rats were kept as a normal control group (n=6, remained naive until tissue collection). The rats were killed at the 1st, 3rd, and 7th days after challenge. The temporal bones in each group were harvested and examined histopathologically by hematoxyline-eosin stain. Middle ear mucosa were taken at the 1st, 3rd, and 7th days after challenge. The levels of spicing variants of TNF-α transcription were evaluated by Realtime-PCR.
Results : TSE suppressed LPS-induced TNF-α mRNA expression and thickness of the submucosal layer and infiltration of inflammatory cells in rat middle ear epithelium.
Conclusion : The results suggest that TSE may be effective in decreasing inflammation with particular application to mucosal metaplasia in OM.
목차
Introduction
Materials and Methods
Results
Discussion
Conclusion
References
참고문헌 (37)
참고문헌 신청
1. [학술지(정기간행물)] - Barrett TQ / 2003 / NFkappa B in cultivated middle ear epithelium / Int J Pediatr Otorhinolaryngol 67 (8) : 895 ~ 903
2. [학술지(정기간행물)] - Daly KA / 1991 / Epidemiology of otitis media / Otolaryngol Clin North Am 24 (4) : 775 ~ 786
3. [학술지(정기간행물)] - Richard M / 2004 / Clinical practice guideline: Otitis media with effusion / Otolaryngology-Head and Neck Surgery 130 (5) : 95 ~ 118
4. [학술지(정기간행물)] - Tos M / 1972 / The pathogenesis of chronic secretory otitis media / Arch Otolaryngol Head Neck Surg 95 : 511 ~ 521
5. [학술지(정기간행물)] - Maeda K / 2004 / Cytokine expression in experi- mental chronic otitis media with effusion in mice / Laryngoscope 114 (11) : 1967 ~ 1972
2. [학술지(정기간행물)] - Daly KA / 1991 / Epidemiology of otitis media / Otolaryngol Clin North Am 24 (4) : 775 ~ 786
3. [학술지(정기간행물)] - Richard M / 2004 / Clinical practice guideline: Otitis media with effusion / Otolaryngology-Head and Neck Surgery 130 (5) : 95 ~ 118
4. [학술지(정기간행물)] - Tos M / 1972 / The pathogenesis of chronic secretory otitis media / Arch Otolaryngol Head Neck Surg 95 : 511 ~ 521
5. [학술지(정기간행물)] - Maeda K / 2004 / Cytokine expression in experi- mental chronic otitis media with effusion in mice / Laryngoscope 114 (11) : 1967 ~ 1972
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UCI(KEPA) : I410-ECN-0101-2014-519-000263657